Springer Seminars in Immunopathology

, Volume 5, Issue 4, pp 413–431 | Cite as

The thyrotrophin receptor

  • Simon W. W. Manley
  • Allison Knight
  • Duncan D. Adams
Article

Conclusion

Two decades of investigation of the TSH receptor as an autoantigen have led not only to elucidation of the pathogenesis of Graves' disease but also to a general theory of autoimmunity. The H-gene theory [10] indicates a strategy for the treatment of autoimmune disease by intervention in the network of paratope-idiotope interactions controlling clonal deletions [54].

In the past 10 years, investigation of the hormone-binding function of the receptor has demonstrated the mechanism of action of the thyroid-stimulating autoantibodies, and provided the basis for the convenient radioreceptor assay of TSaab. This technique has yet to achieve its apparent potential, but the widely-used methodology has been essentially unchanged since 1973 [80]. Recent work has shown improvements in receptor abundance, affinity, and specificity are achievable by manipulation of ionic strength [100], observations which may provide the key to eliminating the major failings of the radioreceptor assay, namely sensitivity and the nonspecific effect of normal control globulins.

Since the amounts of TSH receptor in thyroid tissue are minute, it is unlikely that purification to homogeneity will be achieved in the near future. Nevertheless, the recent demonstrations of receptor heterogeneity [37, 79] and the possible role of gangliosides of known simple structure in receptor function suggest that new and important insights into hormone-receptor interaction may still be forthcoming from the study of TSH receptors.

Keywords

Recent Work Autoimmune Disease Ionic Strength Normal Control General Theory 

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References

  1. 1.
    Adams DD (1958) The presence of an abnormal thyroid-stimulating hormone in the serum of some thyrotoxic patients. J Clin Endocrinol Metab 18: 699PubMedGoogle Scholar
  2. 2.
    Adams DD (1960) A comparison of the rates at which thyrotrophin and the human abnormal thyroid-stimulator disappear from the circulating blood of the rat. Endocrinology 66: 658PubMedGoogle Scholar
  3. 3.
    Adams DD (1980) Thyroid-stimulating autoantibodies. Vitam Horm 38: 119PubMedGoogle Scholar
  4. 4.
    Adams DD (to be published) Autoimmune mechanisms in autoimmune endocrine disease. Davies TF (ed). Wiley, New YorkGoogle Scholar
  5. 5.
    Adams DD, Fastier FN, Howie JB, Kennedy TH, Kilpatrick JA, Stewart RDH (1974) Stimulation of the human thyroid by infusions of plasma containing LATS protector. J Clin Endocrinol Metab 39: 826PubMedGoogle Scholar
  6. 6.
    Adams DD, Kennedy TH (1962) Association of long-acting thyroid-stimulator with the gammaglobulin fraction of serum. Proc Univ Otago Med Sch 40: 6Google Scholar
  7. 7.
    Adams DD, Kennedy TH (1967) Occurrence in thyrotoxicosis of a gamma-globulin which protects LATS from neutralization by an extract of thyroid gland. J Clin Endocrinol Metab 27: 173PubMedGoogle Scholar
  8. 8.
    Adams DD, Kennedy TH (1971) Evidence to suggest that LATS protector stimulates the human thyroid gland. J Clin Endocrinol Metab 33: 47PubMedGoogle Scholar
  9. 9.
    Adams DD, Kennedy TH, Stewart RDH (1974) Correlation between long-acting thyroid stimulator protector level and thyroid131I uptake in thyrotoxicosis. Br Med J 11: 199Google Scholar
  10. 10.
    Adams DD, Knight JG (1980) H gene theory of inherited autoimmune disease. Lancet i 396Google Scholar
  11. 11.
    Adams DD, Purves HD (1956) Abnormal responses in the assay of thyrotrophin. Proc Univ Otago Med Sch 34: 11Google Scholar
  12. 12.
    Adlkofer F, Kotulla P, Schleusener H (1980) Binding of thyrotrophin to low molecular weight fragments of human thyroid membranes. Acta Endocrinol (Copenh) 94: 58Google Scholar
  13. 13.
    Aloj SM, Kohn LD, Lee G, Meldolesi MF (1977) The binding of thyrotrophin to liposomes containing gangliosides. Biochem Biophys Res Commun 74: 1053PubMedGoogle Scholar
  14. 14.
    Amir SM, Carraway TF, Kohn LD, Winand RJ (1973) The binding of thyrotrophin to isolated bovine thyroid plasma membranes. J Biol Chem 248: 4092PubMedGoogle Scholar
  15. 15.
    Atkinson S, Kendall-Taylor P (1981) The stimulation of thyroid hormone secretion in vitro by thyroid-stimulating antibodies. J Clin Endocrinol Metab 53: 1263PubMedGoogle Scholar
  16. 16.
    Bastomsky CH, McKenzie JM (1967) Cyclic AMP: a mediator of thyroid stimulation by thyrotrophin. Am J Physiol 213: 753PubMedGoogle Scholar
  17. 17.
    Bates RW, Condliffe PG (1966) The physiology and chemistry of thyroid stimulating hormone. In: Harris GW, Donovan BT (eds) The pituitary gland, vol. 1. Butterworths, London, p 374Google Scholar
  18. 18.
    Bitensky L, Alaghband-Zadeh J, Chayen J (1974) Studies on thyroid stimulating hormone and the long-acting thyroid stimulating hormone. Clin Endocrinol (Oxf) 3: 363Google Scholar
  19. 19.
    Bottazzo F, Mann JI, Thorogood M, Baum JD, Doniach D (1978) Autoimmunity in juvenile diabetics and their families. Br Med J 2: 165PubMedGoogle Scholar
  20. 20.
    Bryson JM, Joasoo A, Turtle JR (1976) The thyrotrophin receptor in human thyroid plasma membranes: effect of serum immunoglobulins. Acta Endocrinol (Copenh) 83: 528Google Scholar
  21. 21.
    Burke G (1971) Thyroid stimulators and thyroid stimulation. Acta Endocrinol (Copenh) 66: 558Google Scholar
  22. 22.
    Burnet FM (1959) The clonal selection theory of acquired immunity. University Press, CambridgeGoogle Scholar
  23. 23.
    Condliffe PG, Weintraub BD (1979) Pituitary thyroid-stimulating hormone and other thyroid stimulating substances. In: Gray CH (ed) Hormones in blood. vol. l. Academic Press, London, p 499Google Scholar
  24. 24.
    Ciereszko LS (1945) Preparation of pituitary thyrotropic hormone. J Biol Chem 160: 585Google Scholar
  25. 25.
    Clark, AJ (1937) General pharmacology. In: Heubner W, Schuller J (eds) Handbuch der experimentellen Pharmakologie, vol. IV. Springer, BerlinGoogle Scholar
  26. 26.
    Cuatrecasas P (1973) Interaction ofVibrio cholerae enterotoxin with cell membranes. Biochemistry 12: 3547PubMedGoogle Scholar
  27. 27.
    Dandona P, Mitchell P, El Kabir DJ (1971) The effect of the long-acting thyroid stimulator on the adrenal ascorbic acid of the mouse. Clin Sci 40: 21 pGoogle Scholar
  28. 28.
    Dausset J, Svejgaard A (1977) HLA and disease. Munksgaard, CopenhagenGoogle Scholar
  29. 29.
    Davies TF (1981) Autoantibodies to the human thyrotrophin receptor are not species specific. J Clin Endocrinol Metab 52: 426PubMedGoogle Scholar
  30. 30.
    Davies TF, McLachlan SM, Povey OM, Smith BR, Hall R (1977) The influence of propranolol on the thyrotrophin receptor. Endocrinology 100: 974PubMedGoogle Scholar
  31. 31.
    Davies TF, Smith BR, Hall R (1978) Binding of thyroid stimulators to guinea pig testis and thyroid. Endocrinology 103: 6PubMedGoogle Scholar
  32. 32.
    Dawes PJD, Petersen VB, Rees Smith B, Hall R (1978) Solubilization and partial characterization of human and porcine thyrotrophin receptors. J Endocrinol 78: 89PubMedGoogle Scholar
  33. 33.
    DeMeyts P, Roth J, Neville DM, Gavin GR, Lesniak MA (1973) Insulin interaction with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun 55: 154PubMedGoogle Scholar
  34. 34.
    Dirmikis S, Munro DS (1973) Studies on the binding activity for the long-acting thyroid stimulator. J Endocrinol 58: 577PubMedGoogle Scholar
  35. 35.
    Dirmikis S (1973) Comparative studies on the reduction of the response to the long-acting thyroid stimulator by soluble fractions from human, ovine, bovine, and porcine thyroids. J Endocrinol 59: 589Google Scholar
  36. 36.
    Dirmikis SM, Munro DS (1975) Placental transmission of thyroid-stimulating immunoglobulins. Br Med J 2: 665PubMedGoogle Scholar
  37. 37.
    Drummond RW, McQuade R, Grunwald R, Thomas CG, Nayfeh SN, (1982) Separation of two thyrotrophin binding components from porcine thyroid tissue by affinity chromatography: characterisation of high and low affinity sites. Proc Natl Acad Sci USA 79: 2202PubMedGoogle Scholar
  38. 38.
    Ealey PA, Marshall NJ, Ekins RP (1981) Time-related thyroid stimulation by thyrotrophin and thyroid-stimulating antibodies, as measured by the cytochemical section bioassay. J Clin Endocrinol Metab 52: 483PubMedGoogle Scholar
  39. 39.
    Ehrlich P (1909) Über den jetzigen Stand der Chemotherapie. Ber Dtsch Chem Gesellschaft 42 17Google Scholar
  40. 40.
    Endo K, Kasagi K, Konishi J, Ikekubo K, Okuno T, Takeda Y, Mori T, Torizuka K (1978) Detection and properties of TSH-binding inhibitor immunoglobulins in patients with Graves' disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab 46: 734PubMedGoogle Scholar
  41. 41.
    Etienne-Decerf J, Winand RJ (1937) A sensitive technique for determination of thyroid-stimulating immunoglobulin (TSI) in unfractionated serum. Clin Endocrinol (Oxf) 14: 83Google Scholar
  42. 42.
    Gaddum JH (1937) The quantitative effects of antagonistic drugs. J Physiol (Loud) 89: 7PGoogle Scholar
  43. 43.
    Graves RJ (1835) Clinical lectures. London Med Surg J 7: 513Google Scholar
  44. 44.
    Gross J, Pitt-Rivers R (1953) 3:5:3′-Triiodothyronine. 2. Physiological activity. Biochem J 53: 652PubMedGoogle Scholar
  45. 45.
    Gudernatsch JF (1913) Feeding experiments on tadpoles. II: A further contribution to the knowledge of organs with internal secretion. Am J Anat 15: 431Google Scholar
  46. 46.
    Hardisty CA, Hanford L, Humphries H, Munro DS (1981) Long-acting thyroid stimulator (LATS) and long-acting thyroid stimulator protector (LATSP) in untreated thyrotoxicosis. Clin Endocrinol (Oxf) 14: 631Google Scholar
  47. 47.
    Harington CR (1933) The thyroid gland. Oxford University Press, LondonGoogle Scholar
  48. 48.
    Harington CR, Barger G (1927) Chemistry of thyroxine. III: Constitution and synthesis of thyroxine. Biochem J 21: 852Google Scholar
  49. 49.
    Hart IR, McKenzie JM (1971) Comparison of the effects of thyrotrophin and long-acting thyroid stimulator on guinea pig adipose tissue. Endocrinology 88: 26PubMedGoogle Scholar
  50. 50.
    Hinds WE, Takai N, Rapoport B, Filetti S, Clark OH (1981) Thyroid-stimulating immunoglobulin bioassay using cultured human thyroid cells. J Clin Endocrinol Metab 52: 1204PubMedGoogle Scholar
  51. 51.
    Holmes SD, Dirmikis S, Martin TJ, Munro DS (1979) Effects of human thyroid stimulating hormone and immunoglobulins on adenylate cyclase activity and the accumulation of cyclic AMP in human thyroid membranes and slices. J Endocrinol 79: 121Google Scholar
  52. 52.
    Husby G, Van de Rijn I, Zabriskie JB, Adbin H, Williams RC (1976) Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J Exp Med 144: 1094PubMedGoogle Scholar
  53. 53.
    Jerne NK (1955) The natural selection theory of antibody formation. Proc Natl Acad Sci USA 41: 849Google Scholar
  54. 54.
    Jerne NK (1974) Towards a network theory of the immune system. Ann Inst Pasteur 125c: 373Google Scholar
  55. 55.
    Kahn CR (1976) Membrane receptors for hormones and neurotransmitters. J Cell Biol 70: 261PubMedGoogle Scholar
  56. 56.
    Kahn CR (1977) Receptors for peptide hormones: new insights into the pathophysiology of disease states in man. Ann Intern Med 86: 205PubMedGoogle Scholar
  57. 57.
    Kaplan MH, Frengley JD (1969) Autoimmunity to the heart in cardiac disease: Current concepts of the relation of autoimmunity to rheumatic fever, postcardiotomy and postinfarction syndromes and cardiomyopathies. Am J Cardiol 24: 459PubMedGoogle Scholar
  58. 58.
    Karam S, Petersen MM, Petersen VB, Brennan A, Rees Smith B, Hall R (1980) Multiple forms of hormone-receptor complexes. In: Cumming IA, Funder JW, Mendelsohn FAD (eds) Proc 6th Int Cong Endocr, Abs No 77. Australian Academy of Science, Canberra, p 598Google Scholar
  59. 59.
    Kendall-Taylor P (1972) Adenyl cyclase activity in the mouse thyroid gland. J Endocrinol 52: 533PubMedGoogle Scholar
  60. 60.
    Kendall-Taylor P (1972) Comparison of the effects of various agents on thyroidal adenyl cyclase activity with their effects on thyroid hormone release. J Endocrinol 54: 137PubMedGoogle Scholar
  61. 61.
    Kendall-Taylor P, Munro DS (1970) The action of dibutyryl cyclic 3′,5′-adenosine monophosphate on the mouse thyroid gland in vitro. J Endocrinol 47: 333PubMedGoogle Scholar
  62. 62.
    Kishihara M, Nakao Y, Baba Y, Kobayashi N, Matsukura S, Kuma K, Fugita T (1981) Interaction between thyrotrophin (TSH) binding inhibitor immunoglobulins (TBII) and soluble TSH receptors in fat cells. J Clin Endocrinol Metab 52: 665PubMedGoogle Scholar
  63. 63.
    Kishihara M, Nakao Y, Baba Y, Ohgo S, Matsukura S, Fujita T, Kuma K (1979) Effects of alphaand beta-adrenergic blockers on binding of thyrotrophin to fat cell membrane. Acta Endocrinol (Copenh) 90:240Google Scholar
  64. 64.
    Knight A (1977) Studies on the thyroid-stimulating autoantibodies. PhD Thesis, University of Otago, Dunedin, New ZealandGoogle Scholar
  65. 65.
    Knight A, Adams DD (1973) Infusion of LATS protector and LATS into monkeys. Proc Univ Otago Med Sch 51: 11Google Scholar
  66. 66.
    Knight A, Adams DD (1980) Autoantibodies with intrinsic biological activity. Horm Res 13: 69PubMedGoogle Scholar
  67. 67.
    Knight A, Adams DD (1973) Studies of the speed and reversibility of the reactions between EATS and LATSP and their thyroid antigen, in vitro. Proc Univ Otago Med Sch 51: 49Google Scholar
  68. 68.
    Knight A, Caque WS, Adams DD (1980) Measurement of the thyroid stimulating autoantibodies. In: Rose NR, Friedman H (eds) Manual of clinical immunology 2nd Edition. American Society for Microbiology, 1980, Washington, p 391Google Scholar
  69. 69.
    Kocher T (1910) Ueber Jodbasedow. Arch Klin Chir 92: 1166Google Scholar
  70. 70.
    Koizumi Y, Zakarija M, McKenzie JM (1982) Solubilization, purification, and partial characterization of thyrotropin receptor from bovine and human thyroid glands. Endocrinology 110: 1381PubMedGoogle Scholar
  71. 71.
    Kriss JP, Pleshakov V, Chien JR (1964) Isolation and identification of the long-acting thyroidstimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J Clin Endocrinol Metab 24: 1005PubMedGoogle Scholar
  72. 72.
    Kuzuya N, Chin SC, Ikeda H, Uchimura H, Ito K, Nagataki S (1979) Correlation between thyroid stimulators and 3,5,3′-triiodothyronine suppressibility in patients during treatment for hyperthyroidism with thionamide drugs: comparison of assays by thyroid-stimulating and thyrotrophindisplacing activities. J Clin Endocrinol Metab 48: 706PubMedGoogle Scholar
  73. 73.
    Langley JN (1878) On the physiology of the salivary secretion. Part II. On the mutual antagonism of atropin and pilocarpin, having especial reference to their relations in the submaxillary gland of the cat. J Physiol (Lond) 1: 339Google Scholar
  74. 74.
    Laurberg P, Weeke J (1975) T3 release from thyroid slices as an assay for thyroid stimulators. Scand J Clin Lab Invest 35: 723PubMedGoogle Scholar
  75. 75.
    Ledley FD, Mullin BR, Lee G, Aloj SM, Fishman PH, Hunt LT, Dayhoff MO, Kohn ED (1976) Sequence similarity between choleratoxin and glycoprotein hormones: implications for structure activity relationship and mechanism of action. Biochem Biophys Res Commun 69: 852PubMedGoogle Scholar
  76. 76.
    Lissitsky S, Fayet G, Verrier B (1973) Thyroid stimulating hormone binding to cultured thyroid cells. FEBS Lett 29: 20PubMedGoogle Scholar
  77. 77.
    Macchia E, Fenzi GF, Monzani P, Lippi R, Vitti P, Grasso L, Bartalena L, Baschieri L, Pinchera A (1981) Comparison between thyroid stimulating and TSH-binding inhibiting immunoglobulins of Graves' disease. Clin Endocrinol (Oxf) 15: 175Google Scholar
  78. 78.
    Manley SW (1976) TSH receptors. In: Proceedings of the V International Congress of Endocrinology. Excerpta Media International Congress Series No. 403. Endocrinology 2: 145Google Scholar
  79. 79.
    Manley SW, Bourke JR (1981) Receptor heterogeneity in the human thyroid: differences between thyrotrophin binding sites in membrane and nuclear fractions. J Endocrinol 91: 163PubMedGoogle Scholar
  80. 80.
    Manley SW, Bourke JR, Hawker RW (1973) Interaction of the long-acting thyroid stimulator with the thyroidal thyrotrophin receptor. Proceedings, Endocrine Society of Australia, Abstract 39. vol. lb.Google Scholar
  81. 81.
    Manley SW, Bourke JR, Hawker RW (1972) Reversible binding of labelled and non-labelled thyrotrophin by intact thyroid tissue in vitro. J Endocrinol 55: 555PubMedGoogle Scholar
  82. 82.
    Manley SW, Bourke JR, Hawker RW (1974) The thyrotrophin receptor in guinea-pig thyroid homogenate: general properties. J Endocrinol 61: 419PubMedGoogle Scholar
  83. 83.
    Manley SW, Bourke JR, Hawker RW (1974) The thyrotrophin receptor in guinea-pig thyroid homogenate: interaction with the long-acting thyroid stimulator. J Endocrinol 61: 437PubMedGoogle Scholar
  84. 84.
    McGregor AM, Peterson MM, Capiferr R, Evered DC, Rees Smith B, Hall R (1979) Effects of radioiodine on thyrotropin binding inhibiting immunoglobulins in Graves' disease. Clin Endocrinol (Oxf) 11: 437Google Scholar
  85. 85.
    McGregor AM, Rees Smith B, Hall R, Petersen MM, Miller M, Dewar PJ (1980) Prediction of relapse in hyperthyroid Graves disease. Lancet 1: 1101PubMedGoogle Scholar
  86. 86.
    McKenzie JM (1958) The bioassay of thyrotropin in serum. Endocrinology 63: 372PubMedGoogle Scholar
  87. 87.
    McKenzie JM (1958) Delayed thyroid response to serum from thyrotoxic patients. Endocrinology 62: 865PubMedGoogle Scholar
  88. 88.
    McKenzie JM (1960) Further evidence for a thyroid activator in hyperthyroidism. J Clin Endocrinol Metab 20: 380Google Scholar
  89. 89.
    McKenzie JM, Zakarija M, Sato A (1978) Humoral immunity in Graves' disease. Clin Endocrinol Metab 7: 31PubMedGoogle Scholar
  90. 90.
    Mehdi SQ, Badger J, Kriss JP (1977) Thyrotropin binding and long acting thyroid stimulator absorbing activities in subcellular fractions from isolated thyroid cells and thyroid homogenates. Endocrinology 101: 59–65PubMedGoogle Scholar
  91. 91.
    Mehdi SQ, Nussey SS (1975) A radio-ligand receptor assay for the long-acting thyroid stimulator. Biochem J 145: 105–111PubMedGoogle Scholar
  92. 92.
    Meldolesi ME, Aloj SM, Fishman PH, Brady RO, Kohn LD (1976) Relationship of gangliosides to the structure and function of thyrotrophin receptors: their absence on plasma membranes of a thyroid tumour defective in thyrotrophin receptor activity. Proc Natl Acad Sci USA 73: 4060PubMedGoogle Scholar
  93. 93.
    Mullin BR, Fishman PH, Lee G, Aloj SM, Ledley FD, Winand RJ, Kohn LD, Brady RO (1976) Thyrotropin-ganglioside interactions and their relationship to the structure and function of thyrotropin receptors. Proc Natl Acad Sci USA 73: 842PubMedGoogle Scholar
  94. 94.
    Mukhtar ED, Smith BR, Pyle GA, Hall R, Vice P (1975) Relation of thyroid-stimulating immunoglobulins to thyroid function and effects of surgery, radioiodine, and antithyroid drugs. Lancet i 713Google Scholar
  95. 95.
    O'Donnell J, Trokoudes K, Silverberg J, Row V, Volpe R (1978) Thyrotropin displacement activity of serum immunoglobulins from patients with Graves' disease. J Clin Endocrinol Metab 45: 770Google Scholar
  96. 96.
    Onaya T, Kotani M, Yamada T, Ochi Y (1973) New in vitro tests to detect the thyroid stimulator in sera from hyperthyroid patients by measuring colloid droplet formation and cyclic AMP in human thyroid slices. J Clin Endocrinol Metab 36: 859PubMedGoogle Scholar
  97. 97.
    Orgiazzi J, Williams DE, Chopra IJ, Solomon DH (1976) Human thyroid adenyl cyclasestimulating activity in immunoglobulin G of patients with Graves' disease. J Clin Endocrinol Metab 42: 341PubMedGoogle Scholar
  98. 98.
    Ozawa Y, Maciel RMB, Chopra IJ, Solomon DH, Beall GN (1979) Relationships among immunoglobulin markers in Graves' disease. J Clin Endocrinol Metab 48: 381PubMedGoogle Scholar
  99. 99.
    Pastan I, Katzen R (1967) Activation of adenyl cyclase in thyroid homogenates by thyroidstimulating hormone. Biochem Biophys Res Commun 29: 792Google Scholar
  100. 100.
    Pekonen F, Weintraub BD (1980) Salt-induced exposure of high affinity thyrotropin receptors on human and porcine thyroid membranes. J Biol Chem 255: 8121PubMedGoogle Scholar
  101. 101.
    Pekonen F, Weintraub BD (1979) Thyrotropin receptors on bovine thyroid membranes: two types with different affinities and specificities. Endocrinology 105: 352PubMedGoogle Scholar
  102. 102.
    Petersen MM, Karam S, Davies TF, Rees Smith B, Hall R (1979) The effects of triton on the binding of TSH to the thyroid and testis. FEBS Lett 107: 45PubMedGoogle Scholar
  103. 103.
    Petersen VB, Dawes JD, Smith BR, Hall R (1977) The interaction of thyroid-stimulating antibodies with solubilised human thyrotrophin receptors. FEBS Lett 83: 63PubMedGoogle Scholar
  104. 104.
    Pierce JG (1971) Eli Lilly Lecture: The subunits of pituitary thyrotrophin — their relationship to other glycoprotein hormones. Endocrinology 89: 1331PubMedGoogle Scholar
  105. 105.
    Pollett RJ, Standaert ML, Haase BA (1977) Insulin binding to the human lymphocyte receptor: evaluation of the negative cooperative model. J Biol Chem 252: 5828PubMedGoogle Scholar
  106. 106.
    Poss A Deleers M, Ruysschaert JM (1978) Evidence for a specific interaction between GT1 ganglioside incorporated into bilayer membranes and thyrotrophin. FEBS Lett 86: 160PubMedGoogle Scholar
  107. 107.
    Powell-Jones CHI, Thomas CG, Nayfeh SN (1979) Contribution of negative cooperativity to the thyrotropin-receptor interaction in normal human thyroid: kinetic evaluation. Proc Natl Acad Sci USA 76: 705PubMedGoogle Scholar
  108. 108.
    Purves HD, Griesbach WE (1951) The site of thyrotrophin and gonadotrophin production in the rat pituitary studied by McManus-Hotchkiss staining for glycoprotein. Endocrinology 49: 244PubMedGoogle Scholar
  109. 109.
    Rickards C, Buckland P, Smith BR, Hall R (1981) interaction of Graves' IgG with the thyrotropin receptor. FEBS Lett 127: 17PubMedGoogle Scholar
  110. 110.
    Rundle FF, Pochin EE (1944) The orbital tissues in thyrotoxicosis: A quantitative analysis relating to exophthalmos. Clin Sci 5: 51Google Scholar
  111. 111.
    Scatchard G (1949) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51: 660Google Scholar
  112. 112.
    Shishiba Y, Shimizu T, Yoshimura S, Shizume K (1973) Direct evidence for human thyroidal stimulation by LATS- protector. J Clin Endocrinol Metab 36: 517PubMedGoogle Scholar
  113. 113.
    Smith BR (1981) Thyrotropin receptor antibodies. In: Lefkowitz RJ (ed) Receptor regulation (receptors and recognition), Ser 13, Vol 13. Chapman and Hall, London, p 217Google Scholar
  114. 114.
    Smith BR (1970) The interaction of the long-acting thyroid stimulator (LATS) with thyroid tissue in vitro. J Endocrinol 46: 45PubMedGoogle Scholar
  115. 115.
    Smith BR, Dorrington KJ, Munro DS (1969) The thyroid stimulating properties of long-acting thyroid stimulator and gammaglobulin subunits. Biochim Biophys Acta 192: 277PubMedGoogle Scholar
  116. 116.
    Smith BR, Hall R (1974) Thyroid-stimulating immunoglobulins in Graves' disease. Lancet ii: 427Google Scholar
  117. 117.
    Smith BR, Pyle GA, Petersen VB, Hall R (1977) Interaction of thyroid-stimulating antibodies with the human thyrotrophin receptor. J Endocrinol 75: 401PubMedGoogle Scholar
  118. 118.
    Smith PE (1926) Ablation and transplantation of the hypophysis in the rat. Anat Rec 32: 221Google Scholar
  119. 119.
    Smith PE, Smith IP (1922) The repair and activation of the thyroid in the hypophysectomised tadpole by the parenteral administration of fresh anterior lobe of the bovine hypophysis. J Med Res 43: 267Google Scholar
  120. 120.
    Smyth PA, Neylan D, O'Donovan K (1982) The prevalence of thyroid-stimulating antibodies in goitrous disease assessed by cytochemical section bioassay. J Clin Endocrinol Metab 54: 357PubMedGoogle Scholar
  121. 121.
    Stockle G, Wahl R, Seif FJ (1981) Micromethod of human thyrocyte cultures for detection of thyroid-stimulating antibodies and thyrotrophin. Acta Endocrinol (Copenh) 97: 369Google Scholar
  122. 122.
    Sugenoya A, Kidd A, Row V V, Volpe R (1979) Correlation between thyrotropin-displacing activity and human thyroid-stimulating activity by immunoglobulins from patients with Graves' disease and other thyroid disorders. J Clin Endocrinol Metab 48: 398PubMedGoogle Scholar
  123. 123.
    Svejgaard A, Morling N, Platz P, Ryder LP, Thomsen M (1980) HLA and disease. In: Fougereau M, Dausset J (eds) Immunology '80. Academic Press, London, p 530Google Scholar
  124. 124.
    Tata JR (1974) Isolation of nuclei from liver and other tissues. Methods in Enzymol 31: 253Google Scholar
  125. 125.
    Tate RL, Holmes JM, Kohn LD, Winand RJ (1975) Characteristics of a solubilised thyrotrophin receptor from bovine thyroid plasma membranes. J Biol Chem 250: 6527PubMedGoogle Scholar
  126. 126.
    Tate RL, Schwartz HI, Holmes JM, Kohn LD, Winand RJ (1975) Thyrotropin receptors in thyroid plasma membranes: characteristics of thyrotropin binding and solubilisation of thyrotropin receptor activity by tryptic digestion. J Biol Chem 250: 6509PubMedGoogle Scholar
  127. 127.
    Teng CS, Smith BR, Anderson J, Hall R (1975) Comparison of thyrotrophin receptors in membranes prepared from fat and thyroid tissue. Biochem Biophys Res Common 66: 836Google Scholar
  128. 128.
    Toccafondi RS, Aterini S, Medici MA, Rotella CM, Tanini A, Zonefrati R (1980) Thyroid-stimulating antibody (TSAB) detected in sera of Graves' patients using human thyroid cell cultures. Clin Exp Immunol 40: 532PubMedGoogle Scholar
  129. 129.
    Trokoudes KM, Sugenoya A, Hazani E, Row VV, Volpe R (1979) Thyroid-stimulating hormone (TSH) binding to extrathyroidal human tissues: TSH and thyroid stimulating immunoglobulin effects on adenosine 3′5′ monophosphate in testicular and adrenal tissues. J Clin Endocrinol Metab 48: 919PubMedGoogle Scholar
  130. 130.
    Von Basedow (1840) Exophthalmos durch Hypertrophic des Zellgewebes in der Augenhöhle. Woche Ges Heilk (Gasper) 197: 220Google Scholar
  131. 131.
    Yavin E, Yavin Z, Schneider MD, Kohn L (1981) Monoclonal antibodies to the thyrotrophin receptor: Implications for receptor structure and the action of autoantibodies in Graves' disease. Proc Natl Acad Sci USA 78: 3180PubMedGoogle Scholar
  132. 132.
    Zakarija M, McKenzie JM (1978) Zoological specificity of human thyroid-stimulating antibody. J Clin Endocrinol Metab 47: 249PubMedGoogle Scholar
  133. 133.
    Zakarija M, McKenzie JM, Banovac K (1980) Clinical significance of assay of thyroid-stimulating antibody in Graves' disease. Ann Intern Med 93: 28PubMedGoogle Scholar
  134. 134.
    Zinkernagel RM, Doherty PC (1974) Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic chorio-meningitis within a syngeneic or semi-allogeneic system. Nature 248: 701PubMedGoogle Scholar
  135. 135.
    Zor U, Kaneko T, Lowe JB, Bloom G, Field JB (1969) Effect of thyroid-stimulating hormone and prostaglandins on thyroid adenyl cyclase activation and cyclic adenosine 3′,5′-monophosphate. J Biol Chem 244: 5189PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Simon W. W. Manley
    • 1
  • Allison Knight
    • 2
  • Duncan D. Adams
    • 2
  1. 1.Department of Physiology and PharmacologyUniversity of QueenslandBrisbaneAustralia
  2. 2.MRC Autoimmunity Research UnitOtago University Medical SchoolDunedinNew Zealand

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