Skip to main content
Log in

Treatment of lymphoid tumors with anti-idiotype antibodies

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Berlin RD, Wood WD (1964) Studies of the pathogenesis of fever. J Exp Med 119: 715

    PubMed  Google Scholar 

  2. Boyse EA, Old LJ (1969) Some aspects of normal and abnormal cell surface genetics. Annu Rev Genet 3: 269

    Google Scholar 

  3. Brown S, Dilley J, Levy R (1980) Immunoglobulin secretion by mouse X human hybridomas: an approach for the production of anti-idiotype reagents useful in monitoring patients with B cell lymphoma. J Immunol 125: 1037

    PubMed  Google Scholar 

  4. Daley MJ, Gebel HM, Lynch RG (1978) Idiotype-specific transplantation resistance to MOPC-315: abrogation by post-immunization thymectomy. J Immunol 120: 1620

    PubMed  Google Scholar 

  5. Fu SM, Winchester RJ, Kunkel HG (1973) Occurrence of surface IgM, IgD and free light chains on human lymphocytes. J Exp Med 139: 451

    Google Scholar 

  6. Galton DAG, Goldman JM, Wiltshaw E, Catovsky D, Henry K, Goldenberg GJ (1974) Prolymphocytic leukaemia. Br J Haematol 27: 7

    PubMed  Google Scholar 

  7. Glennie M, Stevenson FK, Stevenson GT, Virji M (1979) Cross-linking of lymphocytic surface immunoglobulin inhibits its production via a cyclic nucleotide mechanism. Nature 281: 305

    PubMed  Google Scholar 

  8. Glennie MJ, Stevenson GT (1982) Univalent antibodies kill tumor cells in vitro and in vivo. Nature 295: 712

    PubMed  Google Scholar 

  9. Gordon J, Anderson VA, Robinson DSF, Stevenson GT (1982) The influence of antigen density and a comparison of IgG and IgM antibodies in the anti-complementary modulation of lymphocytic surface immunoglobulin. Scand J Immunol 15: 169

    PubMed  Google Scholar 

  10. Gordon J, Anderson VA, Stevenson GT (1982) Loss of surface-bound antibody accompanying the anti-complementary modulation of leukemic B cell immunoglobulin: contrasting effects of antibodies directed against idiotypic and constant regions. J Immunol 128: 2763

    Google Scholar 

  11. Gordon J, Hamblin TJ, Smith JL, Stevenson FK, Stevenson GT (1981) A human B-cell lymphoma synthesizing and expressing surface μ-chain in the absence of detectable light chain. Blood 58: 552

    PubMed  Google Scholar 

  12. Gordon J, Robinson DSF, Stevenson GT (1981) Antigenic modulation of lymphocytic surface immunoglobulin yielding resistance to complement-mediated lysis. I. Characterization with syngeneic and xenogeneic complements. Immunology 42: 7

    PubMed  Google Scholar 

  13. Gordon J, Stevenson GT (1981) Antigenic modulation of lymphocytic surface immunoglobulin yielding resistance to complement-mediated lysis. II: Relationship to redistribution of the antigen. Immunology 42: 13

    PubMed  Google Scholar 

  14. Griffin FM, Griffin JA, Silverstein SC (1976) Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes. J Exp Med 144: 788

    PubMed  Google Scholar 

  15. Hamblin TJ, Abdul-Ahad AK, Gordon J, Stevenson FK, Stevenson GT (1980) Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces. Br J Cancer 42: 495

    PubMed  Google Scholar 

  16. Hamblin T, Gordon J, Stevenson F, Stevenson G (1980) Reduction of blocking factor to immunotherapy by plasma exchange. In: Sieberth HG (ed) Sonderuck aus plasma exchange. F. K. Schattauer Verlag, Stuttgart, p 387

    Google Scholar 

  17. Hannam-Harris AC, Gordon J, Smith JL (1980) Immunoglobulin synthesis by neoplastic B lymphocytes: free light chain synthesis as a marker of B cell differentiation. J Immunol 125: 2177

    PubMed  Google Scholar 

  18. Haughton G, Lanier LL, Babcock GF, Lynes MA (1978) Antigen-induced murine B cell lymphomas. II. Exploitation of the surface idiotype as tumor specific antigen. J Immunol 121: 2358

    PubMed  Google Scholar 

  19. Hough DW, Chapple JC, Stevenson FK, Stevenson GT (1978) Further studies of immunoglobulin synthesis by guinea-pig leukaemic lymphocytes. Immunology 34: 889

    PubMed  Google Scholar 

  20. Hough DW, McIlroy BM, Stevenson GT (1977) Proteolysis of lymphocytic surface immunoglobulin. Immunology 32: 337

    PubMed  Google Scholar 

  21. Isakson PC, Uhr JW, Krolick KA, Finkelman F, Vitetta ES (1980) Acquisition of cell surface IgD after in vitro culture of neoplastic B cells from the murine tumor BCL1. J Exp Med 151: 749

    PubMed  Google Scholar 

  22. Jaffe ES (1982) Hypothesis: follicular lymphomas—are they benign tumors of the lymphoid system? UCLA Symp Mol Cell Biol 24: 91

    Google Scholar 

  23. Koch GLE, Smith MJ (1978) An association between actin and the major histocompatibility antigen H-2. Nature 273: 274

    PubMed  Google Scholar 

  24. Krolick KA, Isakson PC, Uhr JW, Vitetta ES (1979) BCL1, a murine model for chronic lymphocytic leukemia: use of the surface immunoglobulin idiotype for the detection and treatment of tumor. Immunol Rev 48: 81

    PubMed  Google Scholar 

  25. Krolick KA, Uhr JW, Slavin S, Vitetta ES (1982) In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins. J Exp Med 155: 1797

    PubMed  Google Scholar 

  26. Krolick KA, Uhr JW, Vitetta ES (1982) Selective killing of leukaemia cells by antibody-toxin conjugates: implications for autologous bone marrow transplantation. Nature 295: 604

    PubMed  Google Scholar 

  27. Krolick KA, Villemez C, Isakson P, Uhr JW, Vitetta ES (1980) Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin. Proc Natl Acad Sci USA 77: 5419

    PubMed  Google Scholar 

  28. Lamm ME, Boyse EA, Old LJ, Lisowska-Bernstein B, Stockert E (1968) Modulation of TL (thymus-leukemia) antigens by Fab-fragments of TL antibody. J Immunol 101: 99

    PubMed  Google Scholar 

  29. Lanier LL, Babcock GF, Lynes MA, Haughton G (1979) Early detection of the CH1 murine lymphoma by tumor-associated idiotype in the serum. Int J Cancer 24: 53

    PubMed  Google Scholar 

  30. Lanier LL, Babcock GF, Raybourne RB, Arnold LW, Warner NL, Haughton G (1980) Mechanism of B cell lymphoma immunotherapy with passive xenogeneic anti-idiotype serum. J Immunol 125: 1730

    PubMed  Google Scholar 

  31. Lennert K, Stein H (1981) Histopathology of non-Hodkin's lymphomas. Springer Verlag, Berlin

    Google Scholar 

  32. Lobo PI, Westervelt FB, Horwitz DA (1975) Identification of two populations of immunoglobulinbearing lymphocytes in man. J Immunol 114: 116

    PubMed  Google Scholar 

  33. Manaster J, Frühling J, Stryckmans P (1973) Kinetics of lymphocytes in chronic lymphocytic leukemia. I. Equilibrium between blood and a “readily accessible pool”. Blood 41: 425

    PubMed  Google Scholar 

  34. McGaughey C (1974) Feasibility of tumor immunoradiotherapy using radioiodinated antibodies to tumor-specific cell membrane antigens with emphasis on leukemias and early metastases. Oncology 29: 302

    PubMed  Google Scholar 

  35. Melcher U, Uhr JW (1976) Cell surface Ig. XVI. Polypeptide chain structure of mouse IgM and IgD-like molecule. J Immunol 116: 409

    PubMed  Google Scholar 

  36. Miller RA, Maloney DG, Warnke R, Levy R (1982) Treatment ob B-cell lymphoma with monoclonal anti-idiotype antibody. N Engl J Med 306: 517

    PubMed  Google Scholar 

  37. Moolten FL, Caparell NJ, Zajdel SH, Cooperband SR (1975) Antitumor effects of antibodydiphtheria toxin conjugates. II. Immunotherapy with conjugates directed against tumor antigens induced by simian virus 40. J Natl Cancer Inst 55: 473

    PubMed  Google Scholar 

  38. Neville DM, Youle RJ (1982) Monoclonal antibody-ricin or ricin A chain hybrids: kinetic analysis of cell killing for tumor therapy. Immunol Rev 62: 75

    PubMed  Google Scholar 

  39. Paige CJ, Kincade PW, Ralph P (1978) Murine B cell leukemia line with inducible surface immunoglobulin expression. J Immunol 121: 641

    PubMed  Google Scholar 

  40. Palade GE (1982) Problems in intracellular membrane traffic. In: Evered D, Collins GM (eds) Membrane recycling (Ciba Foundation symposium 92). Pitman, London, p 1

    Google Scholar 

  41. Pierson J, Darley T, Stevenson GT, Virji M (1980) Monoclonal immunoglobulin light chains in urine of patients with lymphoma. Br J Cancer 41: 681

    PubMed  Google Scholar 

  42. Ritz J, Schlossman SF (1982) Utilization of monoclonal antibodies in the treatment of leukemia and lymphoma. Blood 59: 1

    PubMed  Google Scholar 

  43. Schreiner GF, Unanue ER (1976) Membrane and cytoplasmic changes in B lymphocytes induced by ligand-surface immunoglobulin interactions. Adv Immunol 24: 37

    PubMed  Google Scholar 

  44. Singer PA, Singer HH, Williamson AR (1980) Different species of messenger RNA encode receptor and secretory IgM μ chains differing at their carboxy termini. Nature 285: 294

    PubMed  Google Scholar 

  45. Stackpole CW, Jacobson JB, Lardis MP (1974) Antigenic modulation in vitro. II. Modulation of thymus-leukemia antigenicity requires complement component C3. J Exp Med 140: 939

    PubMed  Google Scholar 

  46. Stevenson FK, Elliott EV, Stevenson GT (1977) Some effects on leukaemic B lymphocytes of antibodies to defined regions of their surface immunoglobulin. Immunology 32: 549

    PubMed  Google Scholar 

  47. Stevenson FK, Hamblin TJ, Stevenson GT (1981) The nature of the immunoglobulin G on the surface of B lymphocytes in chronic lymphocytic leukemia. J Exp Med 154: 1965

    PubMed  Google Scholar 

  48. Stevenson FK, Hamblin TJ, Stevenson GT, Tutt AL (1980) Extracellular idiotypic immunoglobulin arising from human leukemic B lymphocytes. J Exp Med 152: 1484

    PubMed  Google Scholar 

  49. Stevenson FK, Morris D, Stevenson GT (1980) Immunoglobulin produced by guinea-pig leukaemic B lymphocytes: its source and use as a monitor of tumor load. Immunology 41: 313

    PubMed  Google Scholar 

  50. Stevenson FK, Stevenson GT, Tutt AL (1983) The export of immunoglobulin D by human neoplastic B lymphocytes. J Exp Med 157: 337

    PubMed  Google Scholar 

  51. Stevenson GT, Elliott EV, Stevenson FK (1977) Idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes: a therapeutic target. Fed Proc 36: 2268

    PubMed  Google Scholar 

  52. Stevenson GT, Glennie MJ, Gordon J (1982)) The killing of lymphoma cells by univalent derivatives of tumor-specific antibody. UCLA Symp Mol Cell Biol 24: 459

    Google Scholar 

  53. Stevenson GT, Smith JL, Hamblin TJ (1983) Immunological investigation of lymphoid neoplasms. Churchill Livingstone, Edinburgh

    Google Scholar 

  54. Stevenson GT, Stevenson FK (1975) Antibody to a moleculary-defined antigen confined to a tumour cell surface. Nature 254: 714

    PubMed  Google Scholar 

  55. Strober S, Gronowicz ES, Knapp MR, Slavin S, Vitetta ES, Warnke RA, Kotzin B, Schroder J (1979) Immunobiology of a spontaneous murine B-cell leukemia (BCL1). Immunol Rev 48: 169

    PubMed  Google Scholar 

  56. Taylor RB, Duffus PH, Raff MC, de Petris S (1971) Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody. Nature 233: 225

    Google Scholar 

  57. Theml H, Trepel F, Schick P, Kaboth W, Begemann H (1973) Kinetics of lymphocytes in chronic lymphocytic leukemia: Studies using continuous3H-thymidine infusion in two patients. Blood 42: 623

    PubMed  Google Scholar 

  58. Thorpe PE, Ross WJC (1982) The preparation and cytotoxic properties of antibody-toxin conjugates. Immunol Rev 62: 119

    PubMed  Google Scholar 

  59. Waldmann TA, Strober W, Mocielnicki RP (1972) The renal handling of low molecular weight proteins. II. Disorders of serum protein catabolism in patients with tubular proteinuria, the nephrotic syndrome of uremia. J Clin Invest 51: 2162

    PubMed  Google Scholar 

  60. Wernet P, Feizi T, Kunkel HG (1972) Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays. J Exp Med 136: 650

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stevenson, G.T., Stevenson, F.K. Treatment of lymphoid tumors with anti-idiotype antibodies. Springer Semin Immunopathol 6, 99–115 (1983). https://doi.org/10.1007/BF01857369

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01857369

Keywords

Navigation