Acta Biotheoretica

, Volume 31, Issue 3, pp 181–184 | Cite as

Amphibian regeneration and cellular heterochrony

  • Roy Douglas Pearson
Article
  • 28 Downloads

Abstract

It is posited that the initiating event of amphibian regeneration of a limb, is ‘retrodifferentiation’* of what are to become the developing cells of the blastema. These cells reiterate a larval or premetamorphic ontogenic repertoire, induced by elevated levels of prolactin with adequate innervation. Subsequent redifferentiation of the blastema cells occurs, controlled by thyroxine and innervation.

This temporal displacement of cellular morphologic characters in regeneration should be looked upon as a function of the ability to reiterate larval characters and subsequently metamorphose. If correct, this would explain why amphibians which metamorphose only once, lose the ability to postmetamorphically regenerate. An exception to this,Xenopus laevis, an anuran which can epimorphically regenerate, to some extent, will be discussed.[/p]

Keywords

Elevated Level Prolactin Morphologic Character Thyroxine Xenopus Laevis 

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References

  1. Adle, E.H., K.E. Paschkis and C. Cantarow, (1959). The influence of thyroid hormone and thiouracil on liver regeneration in the rat. - Acta Endocrinol.29, p. 435–441.Google Scholar
  2. Dent, J.N. (1962). Limb regeneration in larvae and metamorphosing individuals of the South African clawed toad. - J. Morphol.110, p. 61–78.PubMedGoogle Scholar
  3. Dent, J.N. (1968). Survey of amphibian metamorphosis. In: W. Etkin and L.I. Gilbert, eds., Metamorphosis. - New York, Meredith Corp.Google Scholar
  4. Gona, A.G., Pearlman, T. and Gona, O. (1973). Effects of prolactin and thyroxine in hypophysectomized and thyroidectomized red efts of the newt Notophthalmus viridescens. - Gen Comp. Endocrinol.20, p. 107–111.PubMedGoogle Scholar
  5. Gould, S.J. (1977). Ontogeny and Phylogeny. - Cambridge, Mass., Harvard University Press.Google Scholar
  6. von Hansemann, D.P. (1892). Uber die anaplasie der geschwulstzellen und die asymmetrische mitose. - Virchows Arch. A.192, p. 436–449.Google Scholar
  7. Loeser, A.A. (1954). A new therapy for prevention of post-operative recurrences in genital and breast cancer. A six year study of prophylactic thyroid treatment. - Br. Med. J.,2, p. 1380–1383.Google Scholar
  8. Maier, C.E. and M. Singer, (1981). The effect of prolactin on the rate of forelimb regeneration in newts exposed to photoperiod extremes. - J. Exp. Zool.216, p. 395–397.PubMedGoogle Scholar
  9. Niwelinski, J. (1958). The effect of prolactin and somatotrophin on regeneration of the forelimb in the newt Triturus alpestris Laur. - Folia Biol.6, p. 9–36.Google Scholar
  10. Pearson, R.D. (1981). Tumourigenesis: the subterfuge of selection. - Acta Bioth.30, p. 171–176.Google Scholar
  11. Pearson, R.D. (1982). Cellular Heterochrony and neoplasia. - Med. Hypoth.8, p. 432–436.Google Scholar
  12. Schotté, O.E. (1926). Hypophysectomie et regeneration chez les batraciens urodéles. - C.R. Soc. Phys. Hist. Nat.43, p. 67–72.Google Scholar
  13. Stewart, W.E. (1981); In vitro studies on the influence of prolactin and other hormones on tail regeneration in adult Notophthalmus viridescens. - M.Sc. thesis, (Zool.), University of Toronto.Google Scholar
  14. Tassava, R.A. and C. Kuenzli, (1979). The effects of prolactin and thyroxine on tail fin height, habitat choice, and forelimb regeneration in the adult newt (Notophthalmus viridescens). - Ohio Acad. Sci.79, p. 32–37.Google Scholar
  15. Tipton, S.R., C.W. Majors and J.L. Smothers, (1959). Effects of thyroid and adrenal cortical hormones on restoration of liver protein and enzyme activity after partial hepatectomy in rats. - Am. J. Phys.197, p. 71–74.Google Scholar
  16. Uriel, J. and J. Berges, (1979). Rat liver: an experimental model of cell retrodifferentiation.- Protides of the Biol. Fluids, 27th Coll. p. 123–128.Google Scholar
  17. Uriel, J. (1979a). Retrodifferentiation and the fetal patterns of gene expression in cancer. - Adv. Cancer Res.29, p. 127–174.PubMedGoogle Scholar
  18. Waterman, A.J. (1965). Prolactin and regeneration of the forelimb of the newt. - Am. Zool.,5, p. 237.Google Scholar
  19. Welsch, C.W. and Nagasawa, H. (1977). Prolactin and murine mammary tumourigenesis: a review. - Cancer Res.37, p. 951–963.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff/Dr W Junk Publishers 1982

Authors and Affiliations

  • Roy Douglas Pearson
    • 1
  1. 1.Science & Medicine LibraryUniversity of Toronto, 7 King's College CircleTorontoCanada

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