Springer Seminars in Immunopathology

, Volume 4, Issue 2, pp 161–179 | Cite as

Physiology and pathology of rheumatoid factors

  • Dennis A. Carson
  • Jean-Louis Pasquali
  • Constantine D. Tsoukas
  • Sherman Fong
  • Susan F. Slovin
  • Simon K. Lawrance
  • Laura Slaughter
  • John H. Vaughan


Internal Medicine Rheumatoid Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations used


rheumatoid factor


anti-idiotypic antibody


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  1. 1.
    Agnello V, Orbetter A, deKanep GI, Powell R, Tan EM, Joslin F (1980) Evidence for a subset of rheumatoid factors that cross-react with DNA-histone and have a distinctive cross-reactive idiotype. J Exp Med 151: 1514PubMedGoogle Scholar
  2. 2.
    Bardwick PA, Bluestein HG, Zvaifler N, Depper JM, Seegmiller JE (1980) Altered regulation of Epstein-Barr virus. Induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells. Arthritis Rheum 23: 626PubMedGoogle Scholar
  3. 3.
    Bird AG, Britton S (1979) A live human B cell activator operating in isolation of other cellular influences. Scand J Immunol 9: 507PubMedGoogle Scholar
  4. 4.
    Bonagura V, Kunkel HG, Pernis B (1980) Pokeweed mitogen induced plasma cells from patients with rheumatoid arthritis contain idiotypes that relate to those of monoclonal IgM with anti-γ-globulin activity. Arthritis Rheum 23: 655 (Abstract)Google Scholar
  5. 5.
    Capra JD, Kehoe JM (1974) Structure of antibodies with shared idiotypy: the complete sequence of the heavy chain variable regions of two immunoglobulin M anti-gamma globulins. Proc Natl Acad Sci USA 71: 4032PubMedGoogle Scholar
  6. 6.
    Carson DA, Lawrance S, Catalano MA, Vaughan JH, Abraham G (1977) Radioimmunoassay of IgG and IgM rheumatoid factors reacting with human IgG. J. immunol 119: 295PubMedGoogle Scholar
  7. 7.
    Carson DA, Lawrance S (1978) Idiotypes in rheumatoid sera. Arthritis Rheum 21: 550 (Abstract)Google Scholar
  8. 8.
    Carson DA, Bayer AS, Eisenberg RA, Lawrance S, Theofilopoulos A (1978) IgG rheumatoid factor in subacute bacterial endocarditis: Relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol 31: 100PubMedGoogle Scholar
  9. 9.
    Carson DA, Lawrance S (1978) Light chain heterogeneity of 19S and 7S anti-γ-globulins in rheumatoid arthritis and subacute bacterial endocarditis. Arthritis Rheum 21: 438PubMedGoogle Scholar
  10. 10.
    Carson DA, Lawrance S, Slaughter L, Vaughan JH (1979) Immunochemical properties of anti-IgG antibodies. In Panayi GS, Johnson PM (eds) Immunopathogenesis of rheumatoid arthritis. Reedbooks, Chertsey p 51Google Scholar
  11. 11.
    Carson DA (1981) Rheumatoid factor. In: Kelley W, Harris EHJr, Ruddy S, Sledge CB (eds) Textbook of rheumatology. Saunders, Philadelphia, p 677Google Scholar
  12. 12.
    Carson DA (to be published) Anti-IgG antibodies. In: Panayi G (ed) Scientific basis of rheumatology. Churchill-Livingstone, LondonGoogle Scholar
  13. 13.
    Clevinger B, Schilling J, Hood L, Davie JM (1970) Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to α(1–3) dextran. J Exp Med 151: 1059CrossRefGoogle Scholar
  14. 14.
    Eisenberg R (1976) The specificity and polyvalency of binding of a monoclonal rheumatoid factor. Immunochemistry 13: 355PubMedGoogle Scholar
  15. 15.
    Fong S, Tsoukas CD, Frincke LA, Lawrance SK, Holbrook TL, Vaughan JH, Carson DA (1981) Age-associated changes in Epstein-Barr virus induced human lymphocyte autoantibody responses. J Immunol 126: 910PubMedGoogle Scholar
  16. 16.
    Forre O, Johnson PM, Natvig JB (1977) A study of the variable heavy chain (VH) regions in human polyclonal IgM rheumatoid factors. Scand J Rheumatol 6: 113PubMedGoogle Scholar
  17. 17.
    Forre O, Dobloug JH, Michaelsen TE, Natvig JB (1979) Evidence for similar idiotypic determinants on different rheumatoid factor populations. Scand J Immunol 9: 281PubMedGoogle Scholar
  18. 18.
    Fu SM, Harley IN (1979) Human cell lines containing Epstein-Barr virus but distinct from the common B cell lymphoblastoid lines. Proc Natl Acad Sci USA 76: 6637PubMedGoogle Scholar
  19. 19.
    Gathings WE, Lawton AR, Cooper MD (1977) Immunofluorescent studies of the development of pre-B cells, B lymphocytes, and immunoglobulin idiotype diversity in humans. Eur J Immunol 7: 804PubMedGoogle Scholar
  20. 20.
    Hannestad K (1969) γM rheumatoid factors reacting with nitrophenyl groups and denatured deoxyribonucleic acid. Ann NY Acad Sci 168: 63PubMedGoogle Scholar
  21. 21.
    Hannestad K, Johannessen A (1976) Polyclonal human antibodies to IgG (rheumatoid factors) which cross-react with cell nuclei. Scand J Immunol 5: 541PubMedGoogle Scholar
  22. 22.
    Johnson PM, Faulk WP (1976) Rheumatoid factor: Its nature, specificity, and production in rheumatoid arthritis. Clin Immunol Immunopathol 6: 414CrossRefPubMedGoogle Scholar
  23. 23.
    Johnson PM (1979) IgM-rheumatoid factors cross-reactive with IgG and a cell nuclear antigen: apparent “masking” in original serum. Scand J Immunol 9: 461PubMedGoogle Scholar
  24. 24.
    Kaplan RA, DeHeer DH, Carson DA, Pangburn MK, Muller-Eberhard HJ, Vaughan JH (1980) Metabolism of C4 and Factor B in rheumatoid arthritis. Arthritis Rheum 23: 911PubMedGoogle Scholar
  25. 25.
    Keightley RG, Cooper MD, Lawton AR (1976) The T cell dependence of B cell differentiation induced by pokeweed mitogen. J Immunol 117: 1538PubMedGoogle Scholar
  26. 26.
    Kirchner H, Tosato G, Blaese RM, Broden S, Magrath IT (1979) Polyclonal immunoglobulin secretion by human B lymphocytes exposed to Epstein-Barr virus in vitro. J. Immunol 122: 1310PubMedGoogle Scholar
  27. 27.
    Kunkel HG, Muller-Eberhard HJ, Fudenberg HH, Tomasi TB (1961) Gamma globulin complexes in rheumatoid arthritis and certain other conditions. J Clin Invest 40: 117PubMedGoogle Scholar
  28. 28.
    Kunkel HG, Agnello V, Joslin FG, Winchester RJ, Capra JD (1973) Cross idiotypic specificity among monoclonal IgM proteins with anti-γ-globulin activity. J Exp Med 137: 331PubMedGoogle Scholar
  29. 29.
    Metzger H (1970) Structure and function of γM macroglobulins. Adv Immunol 12: 57PubMedGoogle Scholar
  30. 30.
    Metzger H (1974) Effect of antigen binding on the properties of antibody. Adv Immunol 18: 169PubMedGoogle Scholar
  31. 31.
    Morito T, Bankhurst AD, Williams RCJr (1979) Studies of human cord blood and adult lymphocyte interactions with in vitro immunoglobulin production. J Clin Invest 64: 990PubMedGoogle Scholar
  32. 32.
    Munthe E, Natvig JB (1971) Characterization of IgG complexes in eluates from rheumatoid tissue Clin Exp Immunol 8: 249PubMedGoogle Scholar
  33. 33.
    Munthe E, Natvig JB (1972) Complement fixing intracellular complexes of IgG rheumatoid factor in rheumatoid plasma cells. Scand J Immunol 1: 217PubMedGoogle Scholar
  34. 34.
    Pasquali J-L, Fong S, Tsoukas CD, Vaughan JH, Carson DA (1980) Inheritance of IgM rheumatoid factor idiotypes. J Clin Invest 66: 863PubMedGoogle Scholar
  35. 35.
    Pope RM, Teller DC, Mannik M (1974) The molecular basis of self-association of antibodies to IgG (rheumatoid factors) in rheumatoid arthritis. Proc Natl Acad Sci USA 71: 517PubMedGoogle Scholar
  36. 36.
    Slaughter L, Carson DA, Jensen FC, Holbrook TL, Vaughan JH (1978) In vitro effects of EpsteinBarr virus on peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal subjects. J Exp Med 148: 1429PubMedGoogle Scholar
  37. 37.
    Sliwinski AJ, Zvaifler NJ (1970) In vivo synthesis of IgG by the rheumatoid synovial membrane. J Clin Invest 76: 304Google Scholar
  38. 38.
    Smiley JD, Sachs C, Ziff MJ (1968) In vitro synthesis of immunoglobulin by rheumatoid synovial membrane. J Clin Invest 47: 624PubMedGoogle Scholar
  39. 39.
    Theofilopoulos A, Carson DA, Tavassoli M, Slovin SF, Speers WC, Jensen FC, Vaughan JH (1980) Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. Arthritis Rheum 23: 1PubMedGoogle Scholar
  40. 40.
    Tosato G, MacGrath IT, Koski IR, Dooley NJ, Blaese RM (1980) B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes. J Clin Invest 66: 383PubMedGoogle Scholar
  41. 41.
    Tsoukas CD, Carson DA, Fong S, Pasquali J-L, Vaughan JH (1980) Cellular requirements for pokeweed mitogen induced autoantibody production in rheumatoid arthritis. J Immunol 125: 1125PubMedGoogle Scholar
  42. 42.
    Waaler E (1940) On the occurrence of a factor in human serum activating the specific agglutination of sheep blood corpuscles. Acta Pathol Microbiol Scand 17: 172Google Scholar
  43. 43.
    Williams RC, Kunkel HG (1962) Rheumatoid factor, complement and conglutinin aberration in patients with subacute bacterial endocarditis. J Clin Invest 41: 666PubMedGoogle Scholar
  44. 44.
    Winchester RJ, Agnello V, Kunkel HG (1970) Gamma globulin complexes in synovial fluids of patients with rheumatoid arthritis. Partial characterization and relationship to lowered complement levels. Cli Exp Immunol 6: 689Google Scholar
  45. 45.
    Zvaifler NJ (1973) The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol 13: 265Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Dennis A. Carson
    • 1
  • Jean-Louis Pasquali
    • 1
  • Constantine D. Tsoukas
    • 1
  • Sherman Fong
    • 1
  • Susan F. Slovin
    • 1
  • Simon K. Lawrance
    • 1
  • Laura Slaughter
    • 1
  • John H. Vaughan
    • 1
  1. 1.Department of Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA

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