Summary
To realize equilibrated metabolic conditions after bilateral Nx, three male mongrel dogs were exclusively fed by parenteral infusions with a dog-specific compound of EAA, glutamate, and/or glucose (0.19 g nitrogen and/or 52–70 kcal per kg and day). Daily dialyses required by infusion volumes up to 65 ml/kg/day were performed by means of a closed batch hemodialysis system (Rhodial 75) and highly permeable membranes (RP 6), which allowed a precise ultrafiltration control and direct dialysate analysis. Comparing the urea nitrogen production in a pre- and post-nephrectomy period with a 4 successive days' schedule of only glucose, followed by amino acid administration, a marked decrease of net urea nitrogen excretion was noted after nephrectomy, when EAA were supplied.
Abbreviations
- EAA:
-
essential amino acids
- TM:
-
tin meat
- Nx:
-
nephrectomy
References
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Pils, P., Draibe, S., Jungers, P. et al. Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs. Res. Exp. Med. 178, 71–74 (1980). https://doi.org/10.1007/BF01856760
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DOI: https://doi.org/10.1007/BF01856760