Summary
Single administration of ethanol or alcoholic beverages (5 g ethanol/kg body weight) induces a decrease of the 24 h excretion of fecal intestinal alkaline phosphatase (I-AP) activity of 28% (P<0.05) in comparison to controls (0.9% saline). Administration of higher amounts of 20% (v/v) ethanol (8 g/kg body weight on 3 consecutive days) yields a decrease of fecal I-AP excretion up to 82% (P<0.005) in comparison to controls (saturated glucose solution). The interpretation of these results as a toxic effect of ethanol to small intestinal mucosa was supported by measurement of enzymatic activity in the small intestinal mucosa and by morphometric data.
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Hufnagel, H., Bode, C., Bode, J.C. et al. Damage of rat small intestine induced by ethanol. Res. Exp. Med. 178, 65–70 (1980). https://doi.org/10.1007/BF01856759
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DOI: https://doi.org/10.1007/BF01856759