Summary
The adaptive response of a diet containing 60% fructose on the activity of those enzymes which are involved in the metabolism of fructose was measured in the liver and in the jejunal mucosa of rats over a period of 12 days. Control animals received isocaloric amounts of glucose or starch. Under fructose feeding there was a marked increase in the activity of fructose-1-phosphate aldolase (3-fold), ketohexokinase (2–3-fold), and triokinase (3-fold) in the jejunal mucosa. In the liver, however, a significant increase in enzyme activity could only be seen for triokinase (2–3-fold), whereas the activity of the other enzymes measured were only slightly or not at all altered. The activity of the three enzymes mentioned above were elevated to a maximum within 3 days after feeding the fructose diet. In the following time of observation no major further changes occurred. The results show that fructose feeding in comparison to a glucose or starch containing diet leads to a marked adaptive increase in the activity of those enzymes, which are involved in the breakdown of fructose, only in the jejunal mucosa.
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Supported by the Deutsche Forschungsgemeinschaft (SFB 122, Teilprojekt C1)
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Bode, C., Bode, J.C., Ohta, W. et al. Adaptive changes of the activity of enzymes involved in fructose metabolism in the liver and jejunal mucosa of rats following fructose feeding. Res. Exp. Med. 178, 55–63 (1980). https://doi.org/10.1007/BF01856758
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DOI: https://doi.org/10.1007/BF01856758