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Rapid elevation of liver hydroxyproline content following a single administration of various chemical carcinogens to rats

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Research in Experimental Medicine

Summary

The liver hydroxyproline content increased 14 days following a single administration of various chemical carcinogens, 2-N-fluorenylacetamide (FAA), 3′-methyl-4-dimethylaminoazobenzene (3′-Me-DAB), diethylnitrosamine (DEN), dimethylnitrosamine (DMN), and thioacetamide, to rats. The rapid elevation of hydroxyproline following FAA administration, which did not induce liver cell necrosis, was accompanied by an increase in liver collagenase activity. These findings are of interest in relation to the regulatory mechanism of liver fibrogenesis.

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Authors and Affiliations

  1. Dept. I of Internal Medicine, Okayama University Medical School, 700, Okayama, Japan

    A. Watanabe, Y. Yamauchi, M. Kobayashi & H. Nagashima

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  1. A. Watanabe
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  2. Y. Yamauchi
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  3. M. Kobayashi
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  4. H. Nagashima
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Watanabe, A., Yamauchi, Y., Kobayashi, M. et al. Rapid elevation of liver hydroxyproline content following a single administration of various chemical carcinogens to rats. Res. Exp. Med. 189, 43–46 (1989). https://doi.org/10.1007/BF01856028

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  • DOI: https://doi.org/10.1007/BF01856028

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