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Research in Experimental Medicine

, Volume 189, Issue 1, pp 43–46 | Cite as

Rapid elevation of liver hydroxyproline content following a single administration of various chemical carcinogens to rats

  • A. Watanabe
  • Y. Yamauchi
  • M. Kobayashi
  • H. Nagashima
Original Papers

Summary

The liver hydroxyproline content increased 14 days following a single administration of various chemical carcinogens, 2-N-fluorenylacetamide (FAA), 3′-methyl-4-dimethylaminoazobenzene (3′-Me-DAB), diethylnitrosamine (DEN), dimethylnitrosamine (DMN), and thioacetamide, to rats. The rapid elevation of hydroxyproline following FAA administration, which did not induce liver cell necrosis, was accompanied by an increase in liver collagenase activity. These findings are of interest in relation to the regulatory mechanism of liver fibrogenesis.

Key words

Fibrosis Carcinogen FAA Hydroxyproline Collagenase 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • A. Watanabe
    • 1
  • Y. Yamauchi
    • 1
  • M. Kobayashi
    • 1
  • H. Nagashima
    • 1
  1. 1.Dept. I of Internal MedicineOkayama University Medical SchoolOkayamaJapan

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