Rapid elevation of liver hydroxyproline content following a single administration of various chemical carcinogens to rats
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The liver hydroxyproline content increased 14 days following a single administration of various chemical carcinogens, 2-N-fluorenylacetamide (FAA), 3′-methyl-4-dimethylaminoazobenzene (3′-Me-DAB), diethylnitrosamine (DEN), dimethylnitrosamine (DMN), and thioacetamide, to rats. The rapid elevation of hydroxyproline following FAA administration, which did not induce liver cell necrosis, was accompanied by an increase in liver collagenase activity. These findings are of interest in relation to the regulatory mechanism of liver fibrogenesis.
Key wordsFibrosis Carcinogen FAA Hydroxyproline Collagenase
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