Summary
The effect of intraportal infusion of norepinephrine (NE) on primary hemostasis in the cirrhotic rat was investigated at standardized liver trauma. Cirrhosis was induced by simultaneous administration of increasing amounts of carbontetrachloride (CCl4) and phenobarbitone. Infusion of norepinephrine took place after cannulation of the gastroduodenal vein. Intraportal infusion of NE resulted in a significant increase in arterial blood pressure and portal pressure in all animals. No difference was observed between cirrhotic and control rats.
Cirrhotic animals bled longer and more profusely as compared with the controls. Infusion of NE resulted in significant decrease in bleeding time and blood loss. NE did not affect hematocrit, hemoglobin, platelet, or white cell count. Platelet aggregation was not influenced by the compound. In conclusion, intraportal infusion of NE proved effective in decreasing hemorrhage at liver trauma in cirrhotic rats.
Similar content being viewed by others
References
Roberts HR, Caderbaum A (1972) The liver and blood coagulation: Physiology and pathology. Gastroenterology 63:297–305
Schwartz S (1981) Biliary tract surgery and cirrhosis. A critical combination. Surgery 90:577–583
Tobe T (1984) Hepatectomy in patients with cirrhotic livers: Clinical and basic observations. Surg Ann 16:177–202
Vagianos C, Zoucas E, Steen S, Bengmark S (1987) Effect of intra-arterial, intra-portal, or combined NE infusion on haemorrhage at experimental liver trauma in the rat. Eur Surg Res 19:124–128
Chatamra K, Proctor E (1981) Phenobarbitone-induced enlargement of the liver in the rat: Its relationship to carbon tetrachloride-induced cirrhosis. Br J Exp Pathol 62:283–288
Proctor E, Chatamra K (1982) High yield micronodular cirrhosis in the rat. Gastroenterology 83:1183–1190
Proctor E, Chatamra K (1984) Standardized micronodular cirrhosis in the rat. Eur Surg Res 16:182–186
Zoucas E, Bergkvist D, Göransson G, Bengmark S (1982) Effect of acute ethanol intoxication on primary haemostasis, coagulation factors and fibrinolytic activity. Eur Surg Res 14:33–44
Kampen EJ van, Zijlstra WG (1961) Standardization of haemoglobinometry. Clin Chim Acta 6:538–540
Steen S (1984) Human vascular a-adrenoreceptors. A study of peripheral arteries and veins in vitro and in vivo. Thesis, Bulletin no 46 from the Dept. of Surgery, Lund University, Lund, Sweden
Reilly DF, McCuskey SR, Cilento VE (1981) Hepatic microvascular regulatory mechanisms. I. Adrenergic mechanisms. Microvasc Res 21:103–116
McCuskey R (1966) A dynamic and static study of hepatic arterioles and sphincters. Am J Anat 119:455–477
Bloch EH (1955) The in vivo microscopic vascular anatomy and physiology of the liver as determined with the quartz rod method of transillumination. Angiology 6:340–349
Koo A, Liang IYS, Cheng KK (1977) Adrenergic mechanisms in the hepatic microcirculation in the rat. Q J Exp Physiol 62:199–208
Author information
Authors and Affiliations
Additional information
Supported by grant no. B86-17X-07183-02 from the Swedish Medical Council
Rights and permissions
About this article
Cite this article
Vagianos, C., Steen, S., Zoucas, E. et al. Control of traumatic liver hemorrhage in the cirrhotic rat by intraportal infusion of norepinephrine. Res. Exp. Med. 187, 339–346 (1987). https://doi.org/10.1007/BF01855659
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01855659