Summary
The serum levels of immunoreactive pancreatic secretory trypsin inhibitor (irPSTI) and immunoreactive cationic trypsin (irCT) were measured in 14 patients admitted for severe acute attacks of ulcerative colitis. Patients with acute colitis had significantly higher irPSTI levels in serum (35 µg/l) as compared with controls (11.5 µg/l), while the serum level of irCT was within normal limits. The normal colonic mucosa recently has been shown to contain irPSTI favoring the theory of an extrapancreatic origin of the increased serum levels of irPSTI in patients with severe active ulcerative colitis.
Similar content being viewed by others
References
Bohe M, Borgström A, Linström C, Ohlsson K (1986) Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells. J Clin Pathol 39:786–793
Borgström A, Ohlsson K (1976) Radioimmunological determination and characterization of cathodal trypsin-like immunoreactivity in normal human plasma. Scand J Clin Lab Invest 36:809–814
Borgström A (1981) The fate of intravenously injected trypsinogens in dog. Scand J Gastroenterol 16:281–287
Eddeland A, Ohlsson K (1978) A radioimmunoassay for measurement of human pancreatic secretory trypsin inhibitor in different body fluids. Hoppe-Seyler's Z Physiol Chem 359:671–675
Eddeland A, Wehlin L (1978) Secretin/cholecystokinin-stimulated secretion of trypsinogen and trypsin inhibitor in pure human pancreatic juice collected by endoscopic retrograde catheterization. Hoppe-Seyler's Z Physiol Chem 359:1653–1658
Huhtala M-L, Pesonen K, Kalkkinen N, Stenman U-H (1982) Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. J Biol Chem 257:13713–13716
Huhtala M-J, Kahanpää K, Seppälä M, Halila H, Stenman U-H (1983) Excretion of a tumor-associated trypsin inhibitor (TATI) in urine of patients with gynecological malignancy. Int J Cancer 31:711–714
Kazal LA, Spicer DS, Brahinsky RA (1948) Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas. J Am Chem Soc 70:3034–3040
Marks WH, Ohlsson K (1983) The elimination of pancreatic secretory trypsin inhibitor from the circulation. A study in man. Scand J Gastroenterol 18:955–959
Matsuda K, Ogowa M, Murata A, Kitahara T, Kosaki G (1983) Elevation of serum immunoreactive pancreatic secretory trypsin inhibitor contents in various malignant diseases. Res Commun Chem Pathol Pharmacol 40:301–305
Ohlsson K, Laurell C-B (1976) The disappearance of enzyme-inhibitor complexes from the circulation of man. Clin Sci Mol Med 51:87–92
Otsuki M, Oka T, Suehiro I, Okabayashi Y, Ohki A, Yuu H, Baba S (1984) Serum pancreatic secretory trypsin inhibitor in pancreatic disease. Clin Chim Acta 142:231–240
Truelove SC, Witts LJ (1955) Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J 2:1041–1048
Author information
Authors and Affiliations
Additional information
Supported by grants from the Swedish Medical Research Council (Project no. 886-17X-03910-14A, principal scientist Prof. K. Ohlsson) and the Medical Faculty, University of Lund, Sweden
Rights and permissions
About this article
Cite this article
Bohe, M. Immunoreactive pancreatic secretory trypsin inhibitor in sera from patients with acute ulcerative colitis. Res. Exp. Med. 187, 55–58 (1987). https://doi.org/10.1007/BF01854969
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01854969