Immunoreactive pancreatic secretory trypsin inhibitor in sera from patients with acute ulcerative colitis
- 13 Downloads
The serum levels of immunoreactive pancreatic secretory trypsin inhibitor (irPSTI) and immunoreactive cationic trypsin (irCT) were measured in 14 patients admitted for severe acute attacks of ulcerative colitis. Patients with acute colitis had significantly higher irPSTI levels in serum (35 µg/l) as compared with controls (11.5 µg/l), while the serum level of irCT was within normal limits. The normal colonic mucosa recently has been shown to contain irPSTI favoring the theory of an extrapancreatic origin of the increased serum levels of irPSTI in patients with severe active ulcerative colitis.
Key wordsColitis Ileostomy content Pancreatic secretory trypsin inhibitor Trypsin
Unable to display preview. Download preview PDF.
- 8.Kazal LA, Spicer DS, Brahinsky RA (1948) Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas. J Am Chem Soc 70:3034–3040Google Scholar
- 13.Truelove SC, Witts LJ (1955) Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J 2:1041–1048Google Scholar