Research in Experimental Medicine

, Volume 185, Issue 2, pp 115–119 | Cite as

Biliary obstruction and susceptibility to biliary sepsis in rats

  • N. Tanaka
  • P. Christensen
  • S. Rydén
  • B. Klöfver-Ståhl
  • S. Bengmark
Original Papers


The effect of retrograde intrabiliary (RI) injection ofE. coli was studied in Sprague-Dawley rats with biliary obstruction of different duration (3 days; 2, 4, and 6 weeks). By the injection of 105 colony-forming units (CFU) immediately after occlusion of the common bile duct (CBD), 15 of 18 normal rats survived without clinical signs of infection. In contrast, six of 11 animals in 3-day obstruction (P = 0.04), seven of 12 in 2-week obstruction (P = 0.02), ten of 12 in both 4-week and 6-week obstruction (P = 0.0004) died ofE. coli sepsis after injection of the same amount of bacteria. Animals with longstanding jaundice (4 and 6 weeks) were more susceptible than those with a shorter duration of jaundice (3 days and 2 weeks,P = 0.04). The results warrant the early decompression of the biliary tract in biliary obstruction.

Key words

Biliary obstruction Biliary sepsis Cholangitis Intrabiliary injection E. coli Rats 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • N. Tanaka
    • 1
  • P. Christensen
    • 2
  • S. Rydén
    • 1
  • B. Klöfver-Ståhl
    • 1
  • S. Bengmark
    • 1
  1. 1.Dept. of SurgeryUniversity of LundLundSweden
  2. 2.Dept. of MicrobiologyUniversity of LundLundSweden

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