The effect of relative bowel rest on collagen metabolism and suture holding capacity in the colonic wall
- 16 Downloads
In a previous experimental study it was shown that bowel rest with low residue diet led to a reduction of the non-collagenous substances in the intact, unoperated colon, while the collagen content remained unchanged. In the cecum, both the collagen content and the non-collagenous substances were markedly increased.
In the present investigation the effect of relative bowel rest on collagen synthesis in the colonic wall was studied. Further, a possible influence on mechanical properties was evaluated. It was found out that bowel rest led to a marked decrease of collagen and protein synthesis in the colon. In the cecum, there was an unchanged collagen synthesis but an increased protein synthesis. It can be deduced that lysis of collagen is decreased in all parts of the colon. The depression of collagen turnover in the colonic wall was not accompanied by measurable changes in mechanical strength. It remains to be studied whether the observed changes in collagen metabolism do affect colonic healing.
Key wordsColon Collagen synthesis Mechanical strength Low residue diet
Unable to display preview. Download preview PDF.
- 3.Blomquist P, Jiborn H, Zederfeldt B (1984) The effect of relative bowel rest on collagen in the colonic wall. Res Exp Med (in press)Google Scholar
- 7.Halsted WS (1887) Circular suture of the intestine—an experimental study. Am J Med Sci 94:436–461Google Scholar
- 13.Lindström CG, Rosengren J-E, Fork F-T (1979) Colon of the rat. An anatomic, histologic and radiographic investigation. Acta Radiol [Diagn] (Stockh) 20:523–536Google Scholar
- 15.Peacock EE, Jr (1968) Dynamic aspects of collagen biology. II. Degradation and metabolism. J Surg Res 7:481–497Google Scholar
- 16.Stragand JJ, Hagemann RF (1977) Effect of luminal contents on colonic cell replacement. Am J Physiol 233:208–211Google Scholar
- 18.Zederfeldt B, Jiborn H, Blomquist P (1982) Effects of different suture techniques on healing of experimental colonic anastomosis. In: Thiede A, Hamelmann H (eds) Moderne Nahtmaterialien und Nahttechniken in der Chirurgie. Springer, Berlin Heidelberg New York, pp 110–121Google Scholar