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Granulocyte progenitors (CFU-D) in neutrophilic leukemoid reaction are hyporesponsive to macrophage-induced inhibition

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Research in Experimental Medicine

Summary

The responsiveness of marrow granulocyte progenitors (CFU-D) to macrophage-derived stimulatory and inhibitory factors has been studied using diffusion chamber technique in 12 patients with neutrophilic leukemoid reaction (with granulocyte count in the range between 10–40 G/l) and ten healthy subjects. CFU-D from patients with neutrophilic leukemoid reaction (NLR) revealed a normal reactivity to colony-stimulating activity, whereas they were hyporesponsive to macrophage-derived indomethacin-sensitive inhibition. This altered response was correlated both with the concentration of granulocyte progenitors in the S phase and with blood neutrophilic leukocytosis. In patients with higher granulocyte count and increased concentration of CFU-D during active DNA synthesis a more pronounced hyporesponsiveness of granulocyte progenitors to macrophage-induced inhibition has been found.

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  1. Dept. of Hematology, Academy of Medicine, 8/12 Szkolna Str., PL-61-833, Poznań, Poland

    J. Hansz & K. Sawiński

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  1. J. Hansz
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  2. K. Sawiński
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Hansz, J., Sawiński, K. Granulocyte progenitors (CFU-D) in neutrophilic leukemoid reaction are hyporesponsive to macrophage-induced inhibition. Res. Exp. Med. 188, 217–225 (1988). https://doi.org/10.1007/BF01852323

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  • DOI: https://doi.org/10.1007/BF01852323

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