Summary
Cardiovascular function was studied in a model of intestinal vascular obstruction in cats. To measure right ventricular end diastolic pressure and maximal dP/dt, a tip transducer catheter was placed into the right ventricle. The intestinal vascular obstruction resulted in shock with decreases of blood pressure, cardiac output, and external cardiac work. Small intestinal mucosal lesions were found in all shocked cats. At an increased preload to the heart, right ventricular function was depressed in shocked cats. The model corresponds to one used earlier in the rat, where cardioinhibitory activity in venous blood was found in vitro. In this corresponding model of intestinal shock in the cat a depressed function of the right ventricle of the heart was found in vivo.
Similar content being viewed by others
References
Albrecht I, Hallbäck M, Julius S, Lundgren Y, Stage L, Weiss L, Folkow B (1975) Arterial pressure, cardiac output, and systemic resistance before and after pithing in normotensive and spontaneously hypertensive rats. Acta Physiol Scand 94:378–385
Arvidsson S, Falk A, Haglind E, Haglund U (1983) The role of serotonin in the feline response to i.v. infusion of liveE. coli. Br J Pharmacol 79:711–718
Bredenberg CE, Taylor GA, Webb WR (1980) The effect of thrombocytopenia on the pulmonary and systemic hemodynamics of canine endotoxin shock. Surgery 87:59–68
Carter D, Einheber A (1966) Intestinal ischemic shock in germ-free animals. Surg Gynecol Obstet 122:66–76
Chiu CJ, McArdle A, Brow R, Scott H, Gurd F (1970) Intestinal mucosal lesions in low flow states. Arch Surg 101:478–483
Falk A, Kaijser B, Myrvold HE, Haglund U (1980) Intestinal vascular and central hemodynamic responses in the cat following i.v. infusion of liveE. coli bacteria. Circ Shock 7:239–250
Falk A, Myrvold HE, Haglund U (1982) Cardiopulmonary function as related to intestinal mucosal lesions in experimental septic shock. Circ Shock 9:419–433
Farnsworth PN, Paulino-Gonzalez CM, Gregersen MI (1960) Fcells values in the normal and splenectomized cat: Relation of Fcells to body size. Proc Soc Exp Biol 104:729–733
Fine J (1967) The intestinal circulation in shock. Gastroenterology 52:454–458
Glantz SA, Parmley WW (1978) Factors which affect the diastolic pressure-volume curve. Circ Res 42:171–180
Haglind E, Haglund U, Lundgren O, Romanus M, Scherstén T (1980) Graded intestinal vascular obstruction. I. Description of an experimental shock model in the rat. Circ Shock 7:83–91
Haglind E, Haglund U, Lundgren O, Scherstén T (1981) Graded intestinal vascular obstruction. II. Effects of antibiotic pretreatment in the rat. Circ Shock 8:41–47
Haglind E, Haglund U, Lundgren O, Scherstén T (1981) Graded intestinal vascular obstruction. IV. An analysis of the pathophysiology in the development of refractory shock. Circ Shock 8:635–646
Haglind E (1981) Intestinal vascular obstruction. Pathophysiological mechanisms in a shock model. Thesis, Göteborg, ISBN 91-7222-370-7
Haglind E, Haglund U, Lundgren O, Scherstén T (1981) Graded intestinal vascular obstruction. III. An analysis of pathogenic mechanisms. Circ Shock 8:335–341
Haglind E, Bengtsson JP, Falk A, Haglund U, Lundgren O, Scherstén T (1983) Right ventricular function and hemodynamic response in intestinal vascular obstruction in cats. Circ Shock 10:239
Haglind E, Falk A, Haglund U (1983) The effects of 5-HT blockade in graded intestinal vascular obstruction in the rat. Acta Chir Scand 149:273–277
Haglund U, Abe T, Åhrén C, Braide I, Lundgren O (1976) The intestinal mucosal lesions in shock. I. Studies on the pathogenesis. Eur Surg Res 8:435–447
Haglund U, Myrvold H, Lundgren O (1978) Cardiac and pulmonary function in regional intestinal shock. Arch Surg 113:963–969
Haglund U, Lundgren O (1978) Intestinal ischemia and shock factors. Fed Proc 37:2729–2733
Janichi JS, Weber KT (1980) The pericardium and ventricular interaction, distensibility, and function. Am J Physiol 238:494–503
Lillehei RC, Longerbeam JK, Block JH, Manax WG (1964) The nature of irreversible shock. Experimental and clinical observations. Ann Surg 160:682–708
Parmley WW, Chuck L, Chatterjee K, Swan HJC, Klausner SC, Glantz SA, Ratshin RA (1976) Acute changes in the diastolic pressure-volume relationship of the left ventricle. Eur J Cardiol [Suppl] 4:105–120
Rådegran K, Bergentz SE, Lewis DH, Ljungqvist U, Olsson P (1971) Pulmonary effects of induced platelet aggregation. Intravascular obstruction or vasoconstriction? Scand J Clin Lab Invest 28:423–427
Siegel S (1956) Nonparametric statistics for the behavioural sciences. McGraw Hill, New York
Swan KG, Barton RW, Reynolds DG (1972) Splanchnic blood flow in experimental shock. Adv Exp Med Biol 23:87–107
Author information
Authors and Affiliations
Additional information
Supported by grants from the Swedish Medical Research Council (project nos. 2855 and 04502); the Faculty of Medicine, University of Göteborg; the Göteborg Medical Society; the Tore Nilson Foundation for Medical Research; and the Albert Nilsson Research Foundation
Rights and permissions
About this article
Cite this article
Haglind, E., Bengtsson, J.P., Falk, A. et al. Intestinal vascular obstruction in the cat. Res. Exp. Med. 186, 285–294 (1986). https://doi.org/10.1007/BF01852305
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01852305