Skip to main content
SpringerLink
Log in

Neo-intima-nachweis nach experimentellem venenersatz durch PTFE-prothesen beim hund

Demonstration of Neo-Intima in PTFE-Prostheses After Venous Replacement in Dogs

  • Original Contributions
  • Published:
Research in Experimental Medicine

Summary

Because of the danger of thrombosis, venous replacement by prostheses is a yet clinically unsolved problem. We tested the PTFE-prosthesis at the positions of vena cava inferior and iliac veins in dogs. Already eight weeks after operation, the inner surface of the prosthesis was covered by a thin neointima, which by light microscopy, scanning and transmission electron microscopy was shown to contain a basal membrane and endothelial cells. This continuous layer may be responsible for the observed low rate of thrombosis. These findings suggest that the PTFE-prosthesis may offer advantages for venous replacement in patients.

Zusammenfassung

Wegen der Thrombosegefahr ist der Venenersatz durch Prothesen ein klinisch noch nicht gelöstes Problem. Wir prüften an Hunden die PTFE-Prothese in Position der Vena cava inferior bzw. der Iliakalvenen. Bereits acht Wochen nach der Operation war die innere Oberfläche der Prothese mit einer dünnen Neo-Intima bedeckt, in welcher durch Lichtmikroskopie, Raster- und Transmissionselektronenmikroskopie eine Basalmembran und Endothelzellen nachgewiesen werden konnten. Diese kontinuierliche Auskleidung könnte für die geringe beobachtete Thrombose-Rate verantwortlich sein. Diese Befunde deuten darauf hin, daß der Einsatz der PTFE-Prothese für den Venenersatz beim Patienten Vorteile bieten könnte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Brieler HS, Thiede A, Parwaresch R (1978) Neue Aspekte bei der Endothelisierung von Kunststoffprothesen (tierexperimentelle Untersuchungen an Ratten). Langenbecks Arch (Suppl) 1978:95–98

  2. Bryant MR jr, Lazemby WD, Howard JM (1958) Experimental replacement of short segments of veins. Arch Surg 76:289–293

    Google Scholar 

  3. Carrell A, Guthrie CC (1906) Uniterminal and biterminal venous transplantation. Surg Gynecol Obstet 2:266–273

    Google Scholar 

  4. Dean RE, Read RC (1963) The influence of increased blood flow on thrombosis in prosthetic grafts (Exhibit). Trans Am Soc Artif Int Organs 9:312–315

    Google Scholar 

  5. Faulkner R et al. (1979) Early failure of expanded polytetrafluoroethylene in femoral vein replacement. Arch Surg 114:939–943

    PubMed  Google Scholar 

  6. Feigl W, Losert U, Puffer P, Sinzinger H, Weisskirchner R (1979) Zur Frage der Genese und weiteren Ausbildung einer arteriellen Neo-Intima im Tierexperiment. Atherogenese 4:41–50

    Google Scholar 

  7. Florey HW, Greer SJ, Kiser J, Poole JCF, Telander R, Werthessen NT (1962) The development of the pseudointima lining fabric grafts of the aorta. Br J Exp Pathol 43:655

    PubMed  Google Scholar 

  8. Florian A, Cohn LH, Dammin GJ, Collins JJ (1976) Small vessel replacement with Gore-Tex (expanded polytetrafluoroethylene). Arch Surg 111:267–270

    PubMed  Google Scholar 

  9. Foster JH, Ekman CA, Scott HW jr (1960) Late behavior of vascular substitutes. Three to five-year follow up of arterial homografts and synthetic prostheses in experimental animals. Ann Surg 151:867–872

    Google Scholar 

  10. Gott VL, Furuse A (1971) Antithrombogenic surfaces: Classifications and in vivo evaluation. Fed Proc 30:1679–1685

    PubMed  Google Scholar 

  11. Hamann H, Vollmar J (1979) Expanded PTFE-Gefäßprothesen. Ein neuer Weg des Arterien- und Venenersatzes. Chirurg 50:249–256

    PubMed  Google Scholar 

  12. Hukes J (1962) Accolement des plaquets aux structures conjonctives perivasculaires. Thromb Diath Haemorrh 8:241–245

    PubMed  Google Scholar 

  13. Hussfeld KJ (1961) Venenprothese bei Cavaverschluß. Münch Med Wochenschr 120:1074–1081

    Google Scholar 

  14. Matsumoto H, Hasegawa T, Fuse K, Yamamoto M, Saigusa M (1973) A new vascular prosthesis for a small caliber artery. Surgery 74:519–523

    PubMed  Google Scholar 

  15. Mitsuoka H, Howard JM (1968) Experimental grafting of the inferior vena cava. Teflon grafts reinforced by plastic rings and a temporary arteriovenous fistula. J Cardiovasc Surg 9:190–195

    Google Scholar 

  16. Norton L, Eisenmann B (1975) Replacement of portal vein during pancreatectomy for carcinoma. Surg 77:280–284

    Google Scholar 

  17. Noszczyk W (1975) Experimental prosthesis of the abdominal segment of the inferior vena cava. Pol Med J 10:140–145

    Google Scholar 

  18. Sauvage IR, Berger KE, Mansfield PB et al. (1974) Future directions in the development of arterial prostheses for small and medium caliber arteries. Surg Clin North Am 54:213–219

    PubMed  Google Scholar 

  19. Sherck JP, Kerstein MD, Stansel HC (1974) The current status of vena cava replacement. Surg 76:209–233

    Google Scholar 

  20. Todd RS, Sive EB, De Jode IR, Danese C, Howard JM (1963) Replacement of segments of the venous system. Arch Surg 87:990–1003

    Google Scholar 

  21. Vollmar J, Loeprecht H, Ditschuneit H, Belohlavek D (1978) Der meso-cavale Shunt — Standardoperation der Zukunft? Chirurg 49:414–419

    PubMed  Google Scholar 

  22. Weibel ER, Palade G (1964) New cytoplasmic components in arterial endothelia. J Cell Biol 23:101–112

    PubMed  Google Scholar 

  23. Wesolowski SF, Fries CC, Liebig WJ, Sawyer PN, Deterling RA (1962) The synthetic vascular graft: New Concepts, new materials. AMA Arch Surg 84:56–59

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Herz- und Gefäßchirurgie und experimentelle Kardiologie, Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, D-2000, Hamburg 20, Bundesrepublik Deutschland

    W. Wolf, G. Jakobs, P. Kalmar & E. O. Schulz

  2. Institut für Pathologie, Universitätsklinik Hamburg-Eppendorf, D-2000, Hamburg, Germany

    H. -J. Schäfer

  3. Chirurgische Forschung, Fa. Ethicon, D-2000, Hamburg, Germany

    N. Dociu

Authors
  1. W. Wolf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. -J. Schäfer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Dociu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Jakobs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Kalmar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. O. Schulz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wolf, W., Schäfer, H.J., Dociu, N. et al. Neo-intima-nachweis nach experimentellem venenersatz durch PTFE-prothesen beim hund. Res. Exp. Med. 182, 49–62 (1983). https://doi.org/10.1007/BF01852287

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01852287

Key words

Schlüsselwörter

Search

Navigation