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The nature of allorosette-forming cells in rats

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Research in Experimental Medicine

Summary

ARFC appear in the spleen after transplantation of organs or tissues and immunization with nucleated cells between isohistogenic rat strains. The allorosette formation of rat spleen cells and T cells, isolated by an Ig-anti-Ig column, was examined. It has been demonstrated that 90% of ARFC are B cells and 10% are T cells. The allorosette phenomenon can therefore be considered an immune reaction concerning predominantly the B-cell system. Allorosetteforming T cells are discussed to be SD-antigen-recognizing cytotoxic T cells.

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Abbreviations

ARFC:

allorosette-forming cells

B:

bursa equivalent-derived

BSA:

bovine serum albumin

ICA:

immuno-cyto-adherence

Ig:

immunoglobulin

LD:

lymphocyte defined

MEM:

minimal essential medium

PBS:

phosphate-buffered saline

SD:

serologically defined

T:

thymus-derived

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Authors and Affiliations

  1. Immunology Branch Dept. of Surgery, University of Cologne, Robert-Koch-Straße 10, D-5000, Köln, Federal Republic of Germany

    K. W. Lempfrid & G. Hermann

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  1. K. W. Lempfrid
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  2. G. Hermann
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Lempfrid, K.W., Hermann, G. The nature of allorosette-forming cells in rats. Res. Exp. Med. 180, 25–30 (1982). https://doi.org/10.1007/BF01852229

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  • DOI: https://doi.org/10.1007/BF01852229

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