Research in Experimental Medicine

, Volume 180, Issue 1, pp 25–30 | Cite as

The nature of allorosette-forming cells in rats

  • K. W. Lempfrid
  • G. Hermann
Original Contributions


ARFC appear in the spleen after transplantation of organs or tissues and immunization with nucleated cells between isohistogenic rat strains. The allorosette formation of rat spleen cells and T cells, isolated by an Ig-anti-Ig column, was examined. It has been demonstrated that 90% of ARFC are B cells and 10% are T cells. The allorosette phenomenon can therefore be considered an immune reaction concerning predominantly the B-cell system. Allorosetteforming T cells are discussed to be SD-antigen-recognizing cytotoxic T cells.

Key words

Rosette formation B-lymphocytes T-lymphocytes Rats Transplantation (allogenic) 

Abbreviations used


allorosette-forming cells


bursa equivalent-derived


bovine serum albumin






lymphocyte defined


minimal essential medium


phosphate-buffered saline


serologically defined




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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. W. Lempfrid
    • 1
  • G. Hermann
    • 1
  1. 1.Immunology Branch Dept. of SurgeryUniversity of CologneKölnFederal Republic of Germany

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