Research in Experimental Medicine

, Volume 180, Issue 1, pp 15–19 | Cite as

Influence of methionine administration on serum alpha-fetoprotein levels in ethionine-injured rats

  • M. Miyazaki
  • A. Watanabe
  • S. Wahid
  • M. Tsunashima
  • J. Sato
Original Contributions


Serum alpha-fetoprotein (AFP) concentrations increased promptly 2 days following a single injection of DL-ethionine (ethionine) in adult female rats. Continuous elevation of serum AFP was also observed on feeding a diet containing 1% ethionine for at least 2–3 weeks. A rise of serum AFP was not found if the diet was supplemented with 2.8% methionine. Furthermore, in rats fed on 1% ethionine for 2 weeks, dietary change to the laboratory chow supplemented with and without 2.8% methionine produced a decrease of increased serum AFP levels.

Key words

Ethionine Liver injury AFP production Methionine Regulation of AFP production 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. Miyazaki
    • 1
  • A. Watanabe
    • 2
  • S. Wahid
    • 1
  • M. Tsunashima
    • 1
  • J. Sato
    • 1
  1. 1.Division of Pathology, Cancer InstituteOkayama University Medical SchoolOkayamaJapan
  2. 2.First Dept. of Internal MedicineOkayama University Medical SchoolOkayamaJapan

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