Summary
In female rats, temporary unilateral ligation of the ureter (by placing part of it into a cranio-caudal slit of the psoas muscle) protects against mercuric chloride-induced nephrocalcinosis (on the side of the obstruction) and prevents mortality.
Zusammenfassung
Bei weiblichen Ratten verhindert die temporäre Unterbindung des Ureters die Entwicklung einer Quecksilberchlorid-induzierten Nephrocalcinose.
Similar content being viewed by others
References
Blau, E. B., Dysart, N., Fish, A., Michael, A., Vernier, R.: Unilateral renal cortical necrosis. Amer. J. Dis. Child.122, 31–33 (1971).
Clarkson, T. W., Magos, L.: The effect of sodium maleate on the renal deposition and excretion of mercury. Brit. J. Pharmacol. Chemother.31, 560–567 (1967).
Ewald, B. H., Mason, R. C.: Ureteral transection, ligation and compensatory renal hypertrophy. Fed. Proc.22, 278 (1963).
Finney, D. J.: The Fisher-Yates test of significance in 2 × 2 contingency tables. Biometrika35, 145–156 (1948).
Garg, B. D., Solymoss, B., Tuchweber, B.: Effect of spironolactone on the distribution and excretion of203HgCl2 in the rat. Arzneimittel-Forsch.21, 815–816 (1971).
Hirasawa, K.: Augmentation of pressor response to renin and increased renin release in rats with mercuric chloride intoxication and with bilateral ureteral ligation. Jap. Circulat. J. (En.)33, 1059–1064 (1969).
Jaenike, J. R.: The renal response to ureteral obstruction: A model for the study of factors which influence glomerular filtration pressure. J. Lab. clin. Med.76, 373–382 (1970).
Passow, H., Rothstein, A., Clarkson, T. W.: The general pharmacology of the heavy metals. Pharmacol. Rev.13, 185–224 (1961).
Rothstein, A., Hayes, A. D.: The metabolism of mercury in the rat studied by isotope technique. J. Pharmacol. exp. Ther.130, 166–176 (1960).
Schubert, G. E., Muller, J. A., Scholl, A., Linden, U.: Seitenverschiedene Nierenschaden nach Serotonininjektion bei einseitiger Hydronephrose. Virchows Arch. Abt. A path. Anat.347, 69–79 (1969).
Selye, H.: On the protective action of testosterone against the kidney damaging effect of sublimate. J. Pharmacol. exp. Ther.68, 454–457 (1940).
Selye, H.: Über den Einfluß lokaler Faktoren bei der Entstehung von Nierensteinen und Gewebsverkalkungen. Z. Urol.50, 440–444 (1957).
Selye, H.: Mercury poisoning: Prevention by spironolactone. Science169, 775–776 (1970).
Selye, H.: Hormones and Resistance. Berlin-Heidelberg-New York: Springer 1971.
Selye, H., Bois, P.: Effect of corticoids upon the resistance of the kidney to sublimate intoxication. J. Lab. clin. Med.49, 263–266 (1957).
Selye, H., Mecs, I., Szabo, S.: Protection by steroids against acute HgCl2 poisoning. Int. Urol. Nephrol.2, 287–301 (1970).
Steffen, J., Adam, W., Knapowski, J., Arasimowicz, C., Warchol, J.: Acute mercury intoxication in the dog; a functional and autoradiographic study. Acta med. pol.6, 15–30 (1965).
Szabo, S., Selye, H.: Inhibition by hypophysectomy of nephrocalcinosis produced by mercuric chloride. Urol. int. (Basel)26, 39–44 (1971).
Swensson, A., Ulfvarson, M.: Experiments with different antidotes in acute poisoning by different mercury compounds. Int. Arch. Gewerbepath. Gewerbehyg.24, 12–50 (1967).
Watchi, J. M., Magder, E., Patte, D., Jungers, P., de Montera, H.: Necrose corticale unilaterale avec integrite des arteres renales et stenose de l'uretere du rein contralateral. Presse méd.77, 1609–1611 (1969).
Wilmer, H. A.: The disappearance of phosphatase from the hydronephrotic kidney. J. exp. Med.78, 225–230 (1943).
Author information
Authors and Affiliations
Additional information
Supported in part by grants from the Medical Research Council of Canada (Block Term Grant MT-1829), the Ministère des Affaires Sociales, Québec, and the Succession J. A. DeSève.
Rights and permissions
About this article
Cite this article
Szabo, S. Prevention of mercuric chloride intoxication by temporary unilateral ureteral ligation. Res. Exp. Med. 158, 321–326 (1972). https://doi.org/10.1007/BF01852215
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01852215