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Research in Experimental Medicine

, Volume 158, Issue 2, pp 152–164 | Cite as

In vitro-Hemmung der durch Fremdserum induzierten Thrombocytenaggregation

  • Kurt N. von Kaulla
  • Joachim Gerloff
Article
  • 10 Downloads

Zusammenfassung

Hundeserum, das präformierte Antikörper gegen Schweinegewebe besitzt, aggregiert Schweineplättchen, ein Vorgang, der mit der Plättchenaggregometrie gemessen werden kann. Die durch Fremdserum ausgelöste Plättchenaggregation kann durch Vorbehandlung des Serums mit synthetischen Fibrinolytica oder durch Zusatz von Pentosanpolysulfoestern (Heparinoide) zum Reaktionssystem teilweise oder vollständig verhindert werden. Beiden Substanzgruppen ist eine hemmende Wirkung auf das Komplementsystem gemeinsam.

Schlüsselwörter

Thrombocytenaggregation Transplantationsantigene Heparinoide Fibrinolytische Substanzen Komplement 

In vitro inhibition of aggregation of thrombocytes induced by xenogenic serum

Summary

Dog serum which contains preformed antibodies against porcine tissues, aggregates pig thrombocytes, a reaction which can be recorded by platelet aggregometry. The platelet aggregation induced by xenogenic serum can be partially or completely prevented by pretreatment of the serum with synthetic fibrinolytic agents or by addition of pentosanpolysulfoester (heparinoids) to the reaction system. Common to both groups of substances is an inhibition of the complement system.

Key words

Platelet aggregation Transplantation antigens Heparinoids Fibrinolytic compounds Complement 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Kurt N. von Kaulla
    • 1
  • Joachim Gerloff
    • 1
    • 2
  1. 1.Department of MedicineUniversity of Colorado School of MedicineDenverUSA
  2. 2.Empfänger eines Stipendiums der Behring-WerkeMarburgGermany

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