Summary
Using a sheep model, platelet sequestration in lungs, liver, kidney, spleen, and brain was studied after the injection of Indium-111-oxine-labeled platelets andE. coli lipopolysaccharide. Immediately following endotoxin-induced shock, platelet sequestration was observed in lungs, liver, and kidney with corresponding decrease in measured Indiun-111-oxine platelets in spleen and circulating blood. There was also a decrease in platelet counts as measured in a phase contrast microscope. The early platelet sequestration in lung, liver, and kidney was followed by platelet disaggregation and another phase of platelet sequestration which continued until the death of the animal. No platelet sequestration was observed in the brain.
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The study has followed the NIH guidelines for the use of experimental animals and was supported by grants MS 008 and MLN 018, Kuwait University Research Council, Kuwait
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Al-Sarraf, A.A., Christenson, J.T. & Owunwanne, A. Early and late platelet sequestration in different organs during endotoxic shock. Res. Exp. Med. 188, 59–66 (1988). https://doi.org/10.1007/BF01852095
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DOI: https://doi.org/10.1007/BF01852095