Summary
Percutaneous absorption of aescin was measured following application of an aqueous solution of tritiated sodium aescinate to the ventral skin of pigs. Following single or repeated application at various intervals, the concentration of total activity, non-volatile activity and aescin activity following TLC was determined in different organs, tissues, blood and urine.
Very high concentrations of aescin were found in skin and muscular tissues underlying the application site. Only low values were measured in internal organs, blood, urine, skin and musculature from other parts of the body. The concentration of non-volatile activity in subcutis is 50–600 and in musculature 10–50 times higher than in blood.
Only 0.5 – 1% is excreted in urine within 24 hours of administration. The calculated total elimination (bile + urine) may be 1 – 2.5% of the dose. Barely one half is excreted as native aescin, the rest as volatile activity and different metabolites.
Similar content being viewed by others
References
Bartek, M.J., LaBudde, J.A., Maibach, H.I.: J. invest. Derm.58 114–123 (1972)
Bethke, S.: Therapiewoche14 671 (1969)
Bray, G.A.: Anal. Biochem.1 279–285 (1960)
Hackländer, Th.: Dissertation, Tierärztl. Hochschule Hannover (1972)
Jakob, F., Fassbender, B.: Fortschr. Med.87 893–894 (1969)
James, M., Marty, J.-P., Wepierre, J.: C.R. Acad. Sci. (D) (Paris)278 2063–2066 (1974)
James, M., Wepierre, J.: Ann. Pharm. franç.32 633–640 (1974)
James, M., Marty, J.-P., Wepierre, J.: C.R. Acad. Sci. (D) (Paris)281 1525–1528 (1975)
Lang, W., Mennicke, W.H.: Arzneim.-Forsch. (Drug Res.)22 1928–1932 (1972)
Lang, W.: Arzneim.-Forsch. (Drug Res.)24 71–76 (1974)
Lorenz, D., Reiffer, F.: Arzneim.-Forsch. (Drug Res.)17 1083–1085 (1967)
Ludwig, H.: Med. Welt21 194–196 (1970)
Michael, R.J.: Ärztl. Prax.22 4863–4864 (1970)
Montagna, W., Yun, J.S.: J. invest. Derm.43 11–21 (1964)
Müscher, C.-H.: Ärztl. Prax.22 970–972 (1970)
Potzel, J.G., Potzel, G.D.: Ärztl. Prax.22 2809–2811 (1970)
Przerwa, M., Arnold, M.: Arzneim.-Forsch. (Drug Res.)25 1048–1053 (1975)
Reis, H.: Ärztl. Prax.21 3033 (1969)
Saalbach, R.: Ärztl. Prax.22 3222–3224 (1970)
Wagner, J., Schlemmer, W., Hoffmann, H.: Arzneim.-Forsch. (Drug Res.)20 205–209 (1970)
Wagner, J., Hoffmann, H., Löw, J.: Hoppe-Seylers Z. physiol. Chem.351 1133–1140 (1970)
Wulff, G., Tschesche, R.: Tetrahedron25 415–436 (1969)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lang, W. Studies on the percutaneous absorption of3H-Aescin in Pigs. Res. Exp. Med. 169, 175–187 (1977). https://doi.org/10.1007/BF01852057
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01852057