Research in Experimental Medicine

, Volume 186, Issue 3, pp 173–178 | Cite as

Effects of chronic administration of a methionine-enkephalin analogue on the zona glomerulosa of the rat adrenal cortex

  • C. Robba
  • G. Mazzocchi
  • G. G. Nussdorfer
Original Papers


The effects of D-ala2-met-enkephalinamide (DALA) on the zona glomerulosa of dexamethasone-ACTH-treated rats were investigated by coupled radioimmunologic and morphometric techniques. Short-term DALA administration provoked a significant increase in the aldosterone plasma level along with a notable lipid droplet depletion in zona glomerulosa cells. Long-term DALA treatment induced a striking hypertrophy of zona glomerulosa cells and a further rise in the blood concentration of aldosterone. These findings seem to indicate that DALA is involved not only in the acute enhancement of aldosterone output but also in the stimulation of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.

Key words

Zona glomerulosa Enkephalins Aldosterone Rat Stereology 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. Robba
    • 1
  • G. Mazzocchi
    • 1
  • G. G. Nussdorfer
    • 1
  1. 1.Department of AnatomyUniversity of PaduaPaduaItaly

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