Research in Experimental Medicine

, Volume 185, Issue 3, pp 217–220 | Cite as

Captopril-induced changes on active and inactive renin in a patient with factor XII congenital deficiency

  • G. M. Patrassi
  • F. Mantero
  • F. Fallo
  • A. Girolami
  • F. H. M. Derkx
Original Papers


A linkage between prorenin, renin, and intrinsic coagulation systems has been suggested recently. We studied the behavior of renin, prorenin, and kallikrein in a patient affected by congenital factor XII deficiency. Captopril test, upright posture, and furosemide administration provoked in our patients changes of renin and prorenin similar to those found in normal and hypertensive subjects. Unchanged kallikrein levels confirmed that no interaction between prorenin activation and factor XII-kallikrein system appears to be present.

Key words

Captopril Active and inactive renin Kallikrein, factor XII congenital deficiency 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. M. Patrassi
    • 1
  • F. Mantero
    • 1
  • F. Fallo
    • 1
  • A. Girolami
    • 1
  • F. H. M. Derkx
    • 2
  1. 1.Institute of Medical SemeioticsUniversity of Padua Medical SchoolPaduaItaly
  2. 2.Dept. of Internal Medicine IUniversity HospitalDijkzigThe Netherlands

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