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Research in Experimental Medicine

, Volume 185, Issue 3, pp 217–220 | Cite as

Captopril-induced changes on active and inactive renin in a patient with factor XII congenital deficiency

  • G. M. Patrassi
  • F. Mantero
  • F. Fallo
  • A. Girolami
  • F. H. M. Derkx
Original Papers
  • 13 Downloads

Summary

A linkage between prorenin, renin, and intrinsic coagulation systems has been suggested recently. We studied the behavior of renin, prorenin, and kallikrein in a patient affected by congenital factor XII deficiency. Captopril test, upright posture, and furosemide administration provoked in our patients changes of renin and prorenin similar to those found in normal and hypertensive subjects. Unchanged kallikrein levels confirmed that no interaction between prorenin activation and factor XII-kallikrein system appears to be present.

Key words

Captopril Active and inactive renin Kallikrein, factor XII congenital deficiency 

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References

  1. 1.
    Derkx FHM, Wenting GJ, Man In't Veld AJ, Gool JMG, Verhoeven RP, Schalekamp MADH (1976) Inactive renin in human plasma. Lancet 2:496–498Google Scholar
  2. 2.
    Sealey JE, Atlas SA, Laragh JH (1980) Prorenin and other large molecular weight forms of renin. Endocr Rev 1:365–391PubMedGoogle Scholar
  3. 3.
    Hsueh WA (1982) Inactive renin in human plasma. Is it prorenin? Minerva Electrolyte Metab 7:169–178Google Scholar
  4. 4.
    Derkx FHM, Bouma BN, Schalekamp MPA, Schalekamp MADH (1979) An intrinsic factor XII-prekallikrein-dependent pathway activates the human plasma renin-angiotensin system. Nature 280:315–316PubMedGoogle Scholar
  5. 5.
    Rumpf KW, Becher K, Kreusch U, Schmidt S, Vetter R, Scheler F (1980) Evidence of a role of plasma kallikrein in the activation of prorenin. Nature 283:482–483PubMedGoogle Scholar
  6. 6.
    Sealey JE, Atlas SA, Laragh JH (1978) Linking the kallikrein and renin systems via activation of inactive renin. Am J Med 65:994–1000PubMedGoogle Scholar
  7. 7.
    Tatemichi SR, Osmond DH (1978) Factor XII in endogenous activation of inactive renin. Lancet 1:1313Google Scholar
  8. 8.
    Sealey JE, Atlas SA, Laragh JH, Silverberg M, Kaplan A (1979) Initiation of plasma prorenin activation by Hageman factor-dependent conversion of plasma prekallikrein to kallikrein. Proc Natl Acad Sci USA 76:5914–5918PubMedGoogle Scholar
  9. 9.
    Derkx FHM, Schalekamp MPA, Bouma BN, Kluft C, Schalekamp MADH (1982) Plasma kallikrein-mediated activation of the renin-angiotensin system does not require prior acidification of prorenin. J Clin Endocrinol Metab 54:343–348PubMedGoogle Scholar
  10. 10.
    Patrassi GM, Vettor R, Padovan D, Girolami A (1982) Contact phase of blood coagulation in diabetes mellitus. Eur J Clin Invest 12:307–311PubMedGoogle Scholar
  11. 11.
    Wilczynski EA, Osmond DH (1980) Activation of prorenin in Fletcher plasma. Med Sci 8:260Google Scholar
  12. 12.
    Leckie BJ (1982) The reversible activation of inactive renin in human plasma: role of acid and of plasma kallikrein and plasmin. Clin Exp Hypertens A4:2133–2147PubMedGoogle Scholar
  13. 13.
    Wong PY, Williams GH, Colman RW (1983) Studies on the renin-angiotensin system in a kininogen-deficient individual. Clin Sci 65:121–126PubMedGoogle Scholar
  14. 14.
    Hsueh WA, Carlson EJ, Ozan VJ (1983) Characterization of inactive renin from human kidney and plasma. J Clin Invest 71:506–517PubMedGoogle Scholar
  15. 15.
    Vidt DG, Bravo EL, Fouard FM (1982) Captopril. N Engl J Med 12:307–311Google Scholar
  16. 16.
    Goldstone R, Horton R, Carlson EJ, Hsueh WA (1983) Reciprocal changes in active and inactive renin after converting enzyme inhibition in normal man. J Clin Endocrinol Metab 56:264–268PubMedGoogle Scholar
  17. 17.
    Sealey JE, Overlack A, Laragh JH, Stumpe KO, Atlas SA (1981) Effect of captopril and aprotinin on inactive renin. J Clin Endocrinol Metab 53:626–630PubMedGoogle Scholar
  18. 18.
    Derkx FHM, Tan-Tjiong L, Wenting GJ, Boomsma F, Man In't Veld AJ, Schalekamp MADH (1983) Asynchronous changes in prorenin and renin secretion after captopril in patients with renal artery stenosis. Hypertension 5:244–256PubMedGoogle Scholar
  19. 19.
    Sealey JE, Atlas SA, Laragh JA (1982) Plasma prorenin: physiological and biochemical characteristics. Clin Sci 63:133s-145sGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. M. Patrassi
    • 1
  • F. Mantero
    • 1
  • F. Fallo
    • 1
  • A. Girolami
    • 1
  • F. H. M. Derkx
    • 2
  1. 1.Institute of Medical SemeioticsUniversity of Padua Medical SchoolPaduaItaly
  2. 2.Dept. of Internal Medicine IUniversity HospitalDijkzigThe Netherlands

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