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Research in Experimental Medicine

, Volume 188, Issue 6, pp 443–450 | Cite as

Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog

  • C. Hall
  • O. Hevrøy
  • N. E. Kløw
  • O. A. Smiseth
Original Papers

Summary

Acute ischemic left ventricular failure was induced in anesthetized dogs by repeated coronary embolization with 50 µm microspheres. Plasma concentrations of atrial natriuretic factor (ANF) were measured by radioimmunoassay of arterial and venous samples before and after failure induction. Heart failure was accompanied by a doubling of arterial ANF concentration, whereas there were only insignificant changes on the venous side. The increase in arterial ANF correlated significantly to the increase in left ventricular end-diastolic pressure, but not to the increase in right atrial pressure. Measurements of pericardial pressure indicated that a pericardial constraint acted to reduce atrial distension and thereby cardiac ANF release during failure.

Key words

Natriuretic peptides, atrial Heart atrium Pericardium Coronary disease Cardiac output, low Dogs 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • C. Hall
    • 1
  • O. Hevrøy
    • 2
  • N. E. Kløw
    • 2
  • O. A. Smiseth
    • 1
  1. 1.Institute for Surgical ResearchUniversity of OsloOslo 1Norway
  2. 2.Dept. of Physiology, Institute of Medical BiologyUniversity of TromsøTromsøNorway

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