Plasma concentrations of atrial natriuretic factor in acute left ventricular failure in the dog
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Acute ischemic left ventricular failure was induced in anesthetized dogs by repeated coronary embolization with 50 µm microspheres. Plasma concentrations of atrial natriuretic factor (ANF) were measured by radioimmunoassay of arterial and venous samples before and after failure induction. Heart failure was accompanied by a doubling of arterial ANF concentration, whereas there were only insignificant changes on the venous side. The increase in arterial ANF correlated significantly to the increase in left ventricular end-diastolic pressure, but not to the increase in right atrial pressure. Measurements of pericardial pressure indicated that a pericardial constraint acted to reduce atrial distension and thereby cardiac ANF release during failure.
Key wordsNatriuretic peptides, atrial Heart atrium Pericardium Coronary disease Cardiac output, low Dogs
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- 10.Hall C, Karlberg BE (1986) Plasma concentrations of angiotensin II and aldosterone during acute left ventricular failure in the dog. Effect of converting enzyme inhibition. Res Exp Med 186:387–395Google Scholar
- 11.Hoit B, Lew W, LeWinter M (1986) Regional variation in pericardial contact pressure. J Am Coll Cardiol 7:205AGoogle Scholar
- 15.Mancini GBJ, McGillem MJ, Bates ER, Weder AB, DeBoe RJ, Grekin RJ (1987) Hormonal responses to cardiac tamponade: Inhibition of release of atrial natriuretic factor despite elevation of atrial pressures. Circulation 4:884–890Google Scholar
- 18.Richards AM, Cleland JGF, Tonolo G, McIntyre GD, Leckie BJ, Dargie HJ, Ball SG, Robertson JIS (1986) Plasma natriuretic peptide in cardiac impairment. Br Med J 293:409–412Google Scholar
- 24.Ugelstad J, Mørk PC, Kaggerud KH, Ellingsen T, Berge A (1980) Swelling of oligomerpolymer particles. New methods of preparation of emulsions and polymer dispersions. Adv Colloid Interface Sci 13:101–140Google Scholar