Summary
The influence of different intrauterine devices (IUDs) on the uterine fibrinolysis has been extensively studied in rodents with two uterine horns. In this experimental model an IUD is inserted into one horn by a surgical procedure including laparotomy and uterotomy. The effect of these two surgical steps on the fibrinolysis in the endometrium determined according to Todd's histochemical fibrin slide technique was studied in the present series comprising 26 rats. The fibrinolytic activity (FA) in the rat uterus was independent of the biopsy site in the uterine horns. However, significant depression of endometrial fibrinolysis was demonstrated 2 weeks after laparotomy, whereas no effect of a tiny incision in the uterine wall was recorded. In conclusion, a sham operation of the control horn in rodent studies on the fibrinolytic effect of IUDs according to this experimental model is not necessary.
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References
Ledger WJ, Virkar KD, Irvin LA (1966) Effect of a plastic intrauterine device upon implantation in the rabbit. Obstet Gynecol 28:521–525
Larsson B, Liedholm P, Åstedt B (1975) Effect of copper and plastic intra-uterine devices on the fibrinolytic activity of the endometrium in the rat. Int J Fertil 20:145–150
Liedholm P, Sjöberg N-O (1977) Fibrinolytic activity in the rabbit uterus and its fluid with and without copper IUD. Contraception 15:215–224
Liedholm P, Sjöberg N-O (1979) Differences in the effect of copper and Progestasert© IUDs on fibrinolytic activity of the endometrium in the rabbit. Contraception 19:443–448
Al-Amood WS, Al-Khateeb E, Chatterjee B, Chatterjee A (1981) Intrauterine contraceptive devices: Failure of unilateral intrauterine device in inducing luteolysis in rabbits, rats and mice. Contraception 23:543–548
Todd AS (1959) The histological localisation of fibrinolysin activator. J Pathol Bacteriol 78:281–283
Pandolfi M (1972) Histochemistry and assay of plasminogen activator(s). Rev Eur Etud Clin Biol 17:254–260
Bonnar J, Kasonde K, Haddon M, Hassanein MK, Allington MJ (1976) Fibrinolytic activity in utero and bleeding complications with intrauterine contraceptive devices. Br J Obstet Gynaecol 83:160–164
Foley ME, Jenkins DM, McNicol GP (1978) Production of fibrinolytic enzymes by macrophages on intrauterine contraceptive devices. Br J Obstet Gynaecol 85:551–556
Kjaeldgaard A, Anker C, Larsson B (1985) Inhibitory effect of progesterone on IUD-induced activation of fibrinolysis in the rat endometrium. (Submitted)
Åberg M, Nilsson IM (1978) Fibrinolytic activity of the vein wall after surgery. Br J Surg 65:259–262
Wu AVO, Mansfield AO (1980) The relationship between the blood and vein wall fibrinolytic activities in response to surgical trauma. Acta Haematol 63:191–195
Nisell H, Larsson B (1978) Role of blood and fibrinogen in development of intraperitonal adhesions in rats. Fertil Steril 30:470–473
Mund-Hoym S, Roberg A (1982) Adhäsionsprophylaxe — Eine vergleichende tierexperimentelle Studie. Res Exp Med (Berl) 181:171–180
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Kjaeldgaard, A., Anker, C. & Larsson, B. Decreased fibrinolytic activity in the rat uterus after laparotomy. Res. Exp. Med. 185, 277–281 (1985). https://doi.org/10.1007/BF01851952
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DOI: https://doi.org/10.1007/BF01851952