Summary
The histamine release from basophils induced by hypo-osmolarity was investigated in 75 healthy persons and in 43 patients with chronic obstructive airway disease. Leukocyte suspensions were diluted with destilled water in cell/water ratio volumen of 1:1, 1:3, and 1:7. Basophils, sequentially treated with increasing amounts of water, show an activation of the release process. A statistically significant age-dependent hypo-osmolar histamine liberation could be demonstrated. Furthermore, a significant higher cell stability was found for the group of patients.
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Heering, P., Zimmermann, I., Bugalho de Almeida, A.A. et al. Cell instability in basophil leukocytes of patients with chronic obstructive airway disease. Res. Exp. Med. 185, 415–423 (1985). https://doi.org/10.1007/BF01851922
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DOI: https://doi.org/10.1007/BF01851922