Adenylate cyclase of human gastric mucosa
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It has been shown that human gastric mucosa contains a prostaglandin-sensitive adenylate cyclase system. Of the prostaglandins tested the Etype induced an about 3–3.5-fold increase of enzyme activity. The prostaglandin A 2 by causing an about 2.5-fold enhancement of cAMP formation and the F-prostaglandins (1.4–2.0-fold stimulation) were less effective in activating the enzyme system.Maximally effective concentrations of histamine and prostaglandin E 2 were additive with respect to enzyme activity indicating that both hormones act via individual adenylate cyclases.
Key wordsAdenylate cyclase Human gastric mucosa Prostaglandins Histamine Cimetidine Peptic ulcer
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