Research in Experimental Medicine

, Volume 173, Issue 2, pp 113–117 | Cite as

Adenylate cyclase of human gastric mucosa

Stimulation by Prostaglandins
  • B. Simon
  • H. Kather


It has been shown that human gastric mucosa contains a prostaglandin-sensitive adenylate cyclase system. Of the prostaglandins tested the Etype induced an about 3–3.5-fold increase of enzyme activity. The prostaglandin A 2 by causing an about 2.5-fold enhancement of cAMP formation and the F-prostaglandins (1.4–2.0-fold stimulation) were less effective in activating the enzyme system.Maximally effective concentrations of histamine and prostaglandin E 2 were additive with respect to enzyme activity indicating that both hormones act via individual adenylate cyclases.

Key words

Adenylate cyclase Human gastric mucosa Prostaglandins Histamine Cimetidine Peptic ulcer 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • B. Simon
    • 1
  • H. Kather
    • 1
  1. 1.Gastroenterologische AbteilungMedizinischen Univ.-Klinik HeidelbergHeidelbergFederal Republic of Germany

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