Summary
The effect of the ε-guanidino acid derivate camostate (FOY 305) on lipolysis of isolated adipocytes was evaluated to test its supposed influence on the reactions of lipid metabolism in experimental shock. Isoprenaline (10−6 M) and theophylline (10−3 M) significantly stimulated lipolysis in vitro. The basal submaximal (isoprenaline 10−6–10−9 M) and maximal (isoprenaline 10−6 M) catecholamine-stimulated lipolysis were not affected by camostate (10−6 M). Furthermore, camostate (0.1–100 × 10−6 M) did not influence half-maximal theophylline-induced lipolysis of the adipocytes. Our findings do not support the suggestion that ε-guanidino acid derivates diminish in shock the increase of free fatty acids in blood via an influence on lipolysis in the peripheral adipose tissue.
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Göke, B., Göke, R. & Lankisch, P.G. Influence of a low molecular weight serine proteinase inhibitor (camostate) on lipolysis of isolated adipocytes. Res. Exp. Med. 185, 503–507 (1985). https://doi.org/10.1007/BF01851856
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DOI: https://doi.org/10.1007/BF01851856