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Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition

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Research in Experimental Medicine

Summary

Rats were subjected to end-to-end intestinal anastomosis. Breaking strength with the sutures in place, i.e., suture-holding capacity, was measured in different groups immediately after suture and after 24 h. The synthetic kallikrein-plasmin inhibitor S-2441, the inhibitor of plasminogen activation tranexamic acid (Cyklokapron), and the metalloprotease inhibitor tiopronin (Thiola), were studied regarding their effect on breaking strength of the intestinal anastomoses. There was a marked decrease in breaking strength at 24 h in the controls. This decrease was diminished by all of the substances tested. Their effect was probably due to an inhibition of collagenase.

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Authors and Affiliations

  1. Dept. of Surgery, University of Lund, Malmö General Hospital, S-21401, Malmö, Sweden

    H. Högström & U. Haglund

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  1. H. Högström
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  2. U. Haglund
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Supported by grants from the Swedish Medical Research Council (Project nos. 640 and 4502, the Syskonen Svenssons foud and the Medical Faculty, University of Lund

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Högström, H., Haglund, U. Early decrease in suture line breaking strength. The effect of proposed collagenase inhibition. Res. Exp. Med. 185, 451–455 (1985). https://doi.org/10.1007/BF01851851

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  • DOI: https://doi.org/10.1007/BF01851851

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