Hyperammonemia-induced cytotoxic brain edema under osmotic opening of blood-brain barrier in dogs
- 50 Downloads
Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier (BBB) resulted in a marked rise in intracranial pressure with exclusion of Evans blue dye. This indicated cytotoxic brain edema. These findings suggest a role for hyperammonemia in cerebral edema during acute liver failure.
Key wordsAcute liver failure Ammonia Brain edema
Unable to display preview. Download preview PDF.