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Research in Experimental Medicine

, Volume 185, Issue 6, pp 425–427 | Cite as

Hyperammonemia-induced cytotoxic brain edema under osmotic opening of blood-brain barrier in dogs

  • M. Fujiwara
  • A. Watanabe
  • T. Shiota
  • Y. Yamauchi
  • H. Nakatsukasa
  • N. Takei
  • K. Kobayashi
  • T. Higashi
  • H. Nagashima
Original Papers

Summary

Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier (BBB) resulted in a marked rise in intracranial pressure with exclusion of Evans blue dye. This indicated cytotoxic brain edema. These findings suggest a role for hyperammonemia in cerebral edema during acute liver failure.

Key words

Acute liver failure Ammonia Brain edema 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. Fujiwara
    • 1
  • A. Watanabe
    • 1
  • T. Shiota
    • 1
  • Y. Yamauchi
    • 1
  • H. Nakatsukasa
    • 1
  • N. Takei
    • 1
  • K. Kobayashi
    • 1
  • T. Higashi
    • 1
  • H. Nagashima
    • 1
  1. 1.First Department of Internal MedicineOkayama University Medical SchoolOkayamaJapan

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