Summary
The number and severity of gastric stress ulcers (= ulcer index) in rats caused by the restraint technique can be reduced by instilling water, hydrochloric acid or Ringer solution intraduodenally during the stress period. This effect is not caused by lower gastric acid, lower blood gastrin and glucagon and most likely not by an improved gastric mucosal microcirculation.
Abbreviations
- UI:
-
Ulcer index
- id:
-
intraduodenal
- Ringer:
-
Ringer solution
- HCl:
-
Hydrochloric acid
- VIP:
-
Vasoactive intestinal peptide
References
Aguilar-Parada E, Eisentraut AM, Unger RH (1969) Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci 257:415
Christofides ND, Sarson DL, Albuquerque RH, Adrian TE, Ghatei MA, Modlin IM, Bloom SR (1979) Release of gastrointestinal hormones following an oral water load. Experientia 35:1521
Domschke W, Greenberg GR, Domschke S, Bloom SR, Mitznegg P, Sprügel W, Demling L (1977) Endogenous acid releases secretin in man. Acta Hepato-Gastroenterol 24:362
Draxler G, Schwille PO, Putz FJ, Scholz D (1978) Urate metabolism and gastric ulcerations as influenced by stress and allopurinol. Results of a pilot study. Res Exp Med 173:285
Ebeid AM, Soeters PB, Murray P, Fischer JE (1977) Release of vasoactive intestinal peptide (VIP) by intraluminal osmotic stimuli. J Surg Res 23:25
Hemmer J, Schwille PO, Schellerer W, Hofmann W (1980) Effects of cimetidine upon gastric secretion and mucosal blood flow in the rat stressed by restraint. Res Exp Med 250:1
Menguy R (1960) Effects of restraint stress on gastric secretion in the rat. Am J Dig Dis 11:911
Brodie DA, Marshall RW, Moreno OM (1962) Effect of restraint stress on gastric acidity in the rat. Am J Physiol 202:812
O'Connor FA, Buchanan KD, Connon JJ, Shahidullah M (1976) Secretin and insulin: Response to intraduodenal acid. Diabetologia 12:145
Osterloh GF, Lagler F, Staemmler M, Helm F (1966) Pharmakologische und toxikologische Untersuchungen über Benzylsäureester-methylsulfat — ein neues Spasmolytikum. Arzneimittelforsch 16:901
Said SI (1978) VIP: Overview. In: Bloom SR (ed) Gut hormones. Livingstone, Edinburgh, p 465
Schaffalitzky de Muckadell OB, Fahrenkrug J, Holst J, Lauritsen KB (1977) Release of vasoactive intestinal polypeptide (VIP) by intraduodenal stimuli. Scand J Gastroent 12:793
Schwille PO, Schellerer W, Steiner H, Reitzenstein M (1976) Rat gastric mucosal oxygen tension, ulcer index, plasma gastrin and glucagon following restraint stress. Influence of vagotomy, splanchnicotomy and exogenous secretin. Res Exp Med 167:149
Schwille PO, Putz FJ, Thun R, Schellerer W, Draxler G, Lang G (1977) Anti-stress ulcer and anti-secretory effect of somatostatin in rats—failure to suppress serum gastrin. Acta Hepato-Gastroenterol 24:259
Schwille PO, Draxler G, Schellerer W, Putz FJ (1978) Augmented stress ulcer index and depressed blood insulin/glucagon ratio in rats by draining gastric juice outside stomach. Horm Metab Res 10:78
Stadil F, Rehfeld JF (1973) Determination of gastrin in serum. Scand J Gastroenterol 8:101
Tague LL, Jacobson EC (1976) Evaluation of14C-aminopyrine clearance for determination of gastric mucosal blood flow. Proc Soc Exp Biol Med 151:707
Woods SC, Porte D jr (1974) Neural control of the endocrine pancreas. Physiol Rev 54:596
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Putz, F.J., Schwille, P.O., Draxler, G. et al. Reduction of gastric stress ulcers by intraduodenal infusion of liquids—observations in a rat model. Res. Exp. Med. 177, 167–171 (1980). https://doi.org/10.1007/BF01851845
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DOI: https://doi.org/10.1007/BF01851845