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Early micro- and macro-angiopathy in the streptozotocin diabetic minipig

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Research in Experimental Medicine

Summary

Streptozotocin diabetes in the minipig constitutes an outstanding model for the study of diabetic angiopathies. Changes which are classifiable as macroangiopathy are evident after 6 months, while the first changes indicative of microangiopathy appear already after about 18 months. The degree of pronouncement of the microangiopathy depends on the duration and severity of the induced diabetes. These results constitute a cogent argument in favour of the “metabolic theory” of the development of diabetic microangiopathy.

Zusammenfassung

Der Streptozotozindiabetes beim Miniaturschwein stellt ein hervorragendes Modell zum Studium der diabetischen Angiopathien dar. Veränderungen, die der Makroangiopathie zuzuordnen sind, sind nach 6 Monaten nachweisbar. Erste Veränderungen im Sinne einer Mikroangiopathie finden sich bereits nach etwa 18 Monaten. Der Ausprägungsgrad der Mikroangiopathie hängt von der Dauer und der Schwere des induzierten Diabetes ab. Diese Ergebnisse sind ein gewichtiges Argument für die „Stoffwechselhypothese“ der Entstehung der diabetischen Mikroangiopathie.

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Authors and Affiliations

  1. Institut und Poliklinik für Arbeitsmedizin, Universität München, Ziemssenstr. 1, D-8000, München 2, Federal Republic of Germany

    M. Marshall

  2. Medizinische Poliklinik, Universität München, Pettenkoferstr. 8a, D-8000, München 2, Federal Republic of Germany

    H. Oberhofer

  3. Lehrstuhl I des Anatomischen Instituts, Universität Freiburg, Albertstr. 17, D-7800, Freiburg, Federal Republic of Germany

    J. Staubesand

Authors
  1. M. Marshall
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  2. H. Oberhofer
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  3. J. Staubesand
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With the support of the Deutsche Forschungsgemeinschaft

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Marshall, M., Oberhofer, H. & Staubesand, J. Early micro- and macro-angiopathy in the streptozotocin diabetic minipig. Res. Exp. Med. 177, 145–158 (1980). https://doi.org/10.1007/BF01851843

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  • DOI: https://doi.org/10.1007/BF01851843

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