Summary
The effect of hypovolemia on the mucosal blood flow of the gastric corpus and antrum were tested with the microsphere method 30 and 60 min after induction of hemorrhagic shock in the rat. The results demonstrate a marked reduction after 30 and 60 min without any significant differences between the corpus and the antrum. This reduction is largely dependent on cardiac and circulatory function. It is concluded that the differences in energy metabolism, which have been implicated as explanation for the different susceptibility to develop stress lesions by Menguy and Masters, cannot be attributed to different degrees of ischemia.
Zusammenfassung
Der Effekt von Hypovolämie auf die Schleimhautdurchblutung von Corpus und Antrum des Rattenmagens wurde mittels der Mikrosphärenmethode 30 und 60 min nach Einleitung eines hämorrhagischen Schocks untersucht. Die Ergebnisse demonstrieren eine deutliche Herabsetzung ohne regionale Unterschiede zwischen Antrum und Corpus. Diese Minderdurchblutung korreliert eng mit der Senkung von Herzzeitvolumen und arteriellem Blutdruck. Regionale Unterschiede im Energiehaushalt der Schleimhaut, die als Erklärung für die im Corpus höhere Anfälligkeit für Stressläsionen herangezogen wurden, können nicht auf regional unterschiedliche Herabsetzung der Durchblutung zurückgeführt werden.
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Abbreviations
- GMBF:
-
gastric mucosal blood flow
- AMBF:
-
antral mucosal blood flow
- CMBF:
-
corpus mucosal blood flow
- CO:
-
cardiac output
- AP:
-
arterial pressure
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Starlinger, M., Jakesz, R., Bratusch-Marrain, P. et al. Regional gastric mucosal blood flow in hypovolemic shock. Res. Exp. Med. 175, 181–185 (1979). https://doi.org/10.1007/BF01851825
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DOI: https://doi.org/10.1007/BF01851825