Summary
The influence of linoleic acid intake on human prostaglandin formation was investigated by gas chromatographic determination of dimethyl tetranorprostanedioate, a derivative of the major urinary end products of prostaglandin metabolism.
Six healthy female volunteers were put on liquid formula diets. Each person had a linoleic acid supply of 0, 10, and 50 g per day for periods of two weeks. At the end of these periods the corresponding average amounts of tetranorprostanedioic acid in urine were 92, 175, and 326 µg per day.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- TNPA:
-
tetranorprostanedioic acid
References
Almé, B., Hansson, G.: Analysis of metabolic profiles of prostaglandins in urine using a lipophilic anion exchanger. Prostaglandins15, 200–217 (1978)
Aizawa, Y., Yamada, K., Hata, M.: Double isotope derivative dilution method for the determination of prostaglandin F and E type metabolites in urine. Prostaglandins14, 1165–1174 (1977)
Friedman, Z., Seyberth, H., Lamberth, E., Oates, J.: Decreased prostaglandin E turnover in infants with essential fatty acid deficiency. Pediat. Res.12, 711–714 (1978)
Fröhlich, T. C., Wilson, T. W., Sweetman, B. J., Smigel, M., Nies, A. S., Carr, K., Watson, J. T., Oates, J. A.: Urinary prostaglandins. Identification and origin. J. Clin. Invest.55, 763–770 (1975)
Granström, E., Kindahl, H.: Radioimmunoassay for urinary metabolites of prostaglandin F 2α . Prostaglandins12, 759–783 (1976)
Hamberg, M., Samuelson, B.: On the metabolism of prostaglandins E1 and E2 in man. J. Biol. Chem.246, 6713–6721 (1971)
Hamberg, M.: Quantitative studies on prostaglandin synthesis in man. Anal. Biochem.55, 368–378 (1973)
Mentz, P., Forster, W.: The influence of unsaturated fatty acids on prostaglandin release in isolated perfused Guinea pig hearts. Prostaglandins14, 173–179 (1977)
Nijkamp, F. P., Moncada, S., White, H. L., Vane, J. R.: Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen, or platelets. Eur. J. Pharmacol.44, 179–186 (1977)
Nugteren, D. H.: The determination of prostaglandin metabolites in human urine. J. Biol. Chem.250, 2808–2812 (1975)
Peskar, B. M.: On the synthesis of prostaglandins by human gastric mucosa and its modification by drugs. Biochim. Biophys. Acta487, 307–314 (1977)
Seyberth, H. W., Sweetmann, B. J., Fröhlich, J. C., Oates, J. A.: Quantification of the major urinary metabolite of the E prostaglandins by mass spectrometry: evaluation of the method's application to clinical studies. Prostaglandins11, 381–388 (1976)
Scherer, B., Schnermann, J., Sofroniev, M., Weber, P. C.: Prostaglandin analysis in urin of humans and rats by different radioimmunoassays: effect on PG-excretion by PG-synthetase inhibitors, laparotomy and furosemide. Prostaglandins15, 255–265 (1978)
Seyberth, H. W., Oelz, O., Kennedy, T., Sweetman, B. J., Danon, A., Fröhlich, J. C., Heimberg, M., Oates, J. A.: Increased arachidonate in lipids after administration to man: effects on prostaglandin biosynthesis. Clin. Pharmacol. Ther.18, 521–529 (1975)
Wolfram, G., Zöllner, N.: Der Linolsäurebedarf des Menschen. In: Polyenfettsäuren. Wiss. Veröff. DGE 22, S. 51–60. Darmstadt: Dr. D. Steinkopff 1971
Zöllner, N., Eberhagen, D.: Untersuchung und Bestimmung der Lipoide im Blut. Berlin-Heidelberg-New York: Springer 1965
Zusman, R. M., Keiser, H. R.: Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. J. Biol. Chem.252, 2069–2071 (1977)
Author information
Authors and Affiliations
Additional information
Supported by a grant from the Deutsche Forschungsgemeinschaft
Rights and permissions
About this article
Cite this article
Zöllner, N., Adam, O. & Wolfram, G. The influence of linoleic acid intake on the excretion of urinary prostaglandin metabolites. Res. Exp. Med. 175, 149–153 (1979). https://doi.org/10.1007/BF01851821
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01851821