Summary
The influence of intra-arterially administered histamine on the permeability of the articular barrier (synovial membrane plus vascular endothelium) was studied in cats. The dye penetration from the blood through the barrier was tested by perfusing the two knee joints with saline; the histamine solution was infused through one of the circumflex branches of the femoral artery. The dye content of the two perfusates was measured colorimetrically, the local blood supply of the two knee joints thermo-electrically.
In the great majority of experiments it was found that the dye excretion was considerably reduced on the histamine-infused side, in spite of marked improvement of blood supply.
Zusammenfassung
Die Wirkung von intraarteriell verabreichtem Histamin auf die Permeabilität der Gelenksbarriere (Synovialmembran + Gefäßendothel) wurde an Katzen untersucht. Die Penetration von Farbstoffen aus dem Blut durch die Barriere wurde mittels Perfusion der beiden Kniegelenke mit normaler Kochsalzlösung geprüft; die Histaminlösung wurde durch die A. circumflexa femoris verabreicht. Die Farbstoffkonzentration der beiden Perfusate wurde kolorimetrisch, die lokale Blutversorgung der Gelenke thermoelektrisch gemessen.
Die überwiegende Mehrzahl der Versuche ergab, daß die Farbstoffausscheidung der mit Histamin behandelten Seite, trotz der bedeutend verbesserten Blutversorgung, stark herabgesetzt war.
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Engel, D. The effects of intra-arterially administered histamine on vascular permeability. Res. Exp. Med. 175, 117–121 (1979). https://doi.org/10.1007/BF01851818
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DOI: https://doi.org/10.1007/BF01851818