Research in Experimental Medicine

, Volume 162, Issue 4, pp 341–346 | Cite as

Fructose induced hyperuricemia

Effects of Fructose on thede novo Synthesis of Adenine Nucleotides in the Liver and Skeletal Muscles of Rats
  • J. D. Schwarzmeier
  • W. Marktl
  • K. Moser
  • A. Lujf


The intravenous infusion of fructose (0.7 and 2.4 g/kg/30 min) increases the incorporation of14C-glycine into rat liver adenine nucleotides significantly as compared to controls treated with 0.9% NaCl. A decrease of the total adenine nucleotide content of the livers occurs concomitantly. In contrast to its effect upon liver tissue fructose neither effects the content of adenine nucleotides nor the incorporation of glycine into these nucleotides in skeletal muscle of rats. — The results support the hypothesis that large quantities of fructose cause an increasedde novo synthesis of purine nucleotides in the liver. However, they do not as yet present clear cut evidence as to whether this is a direct effect of fructose or is secondary to the depletion of adenine nucleotides.

Key words

Fructose Purine synthesisde novo Adenine nucleotides Rat liver Rat muscles Hyperuricemia 


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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • J. D. Schwarzmeier
    • 1
  • W. Marktl
    • 1
  • K. Moser
    • 1
  • A. Lujf
    • 1
  1. 1.I. Medizinische Klinik und Physiologisches Institut der UniversitätWienAustria

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