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Smooth muscle cell regeneration in repair of gastric anastomosis in the dog

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Research in Experimental Medicine

Summary

Tissue repair process after experimental transection of the stomach in dogs has been studied histologically and electron microscopically. Initially the incision gap is observed to be filled with loose connective tissue, in which smooth muscle cells (sm.m.c.) soon appear. On the 6th day after the operation single sm.m.c. are found dispersed among the polymorphous cell elements of the granulation tissue, comprising the area of the anastomosis. With the advance of the restorative process, increased number of sm.m.c. invides the connective tissue, replacing the defect. On the 9th and 12th days, islets of sm.m.c., often cone-shaped, adjacent with their bases to the normal muscular layer are observed in the connective tissue and within 30 to 90 days, bundles of sm.m.c., alternating with connective tissue, overbridge the operative defect and connect both edges of the transected gastric wall.

The participation of the sm.m.c. in the process of repair of the gastric wall appears to be result of mitotic division of sm.m.c. from the transected muscular gastric layer and of migration of the new sm.m.c. into the focus of injury.

Contrary to most concepts, that sm.m.c., as highly differentiated postmitotic cells, are restricted in their division capacity, the results of the present study indicate, that sm.m.c. in the mature organism of mammals preserve their ability for regeneration proper.

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Authors and Affiliations

  1. Department of Cardiovascular Diseases, Academy of Medicine, G. Sofiiski str. 1, Sofia 31, Bulgaria

    Z. Jurukova & E. Atanassova

  2. Institute of Physiology, Bulgarian Academy of Sciences, Bulgaria

    Z. Jurukova & E. Atanassova

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  1. Z. Jurukova
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  2. E. Atanassova
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Jurukova, Z., Atanassova, E. Smooth muscle cell regeneration in repair of gastric anastomosis in the dog. Res. Exp. Med. 162, 299–312 (1974). https://doi.org/10.1007/BF01851701

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  • DOI: https://doi.org/10.1007/BF01851701

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