Research in Experimental Medicine

, Volume 179, Issue 3, pp 199–204 | Cite as

Decreased complement activity after bilateral renal ischemia in rats

  • Gy. Losonczy
  • E. Pósch
  • L. Hársing
Original Contributions


The bilateral occlusion of the renal arteries for 2 h resulted in a marked decrease of serum complement activity after recirculation. The release of a proteinic factor with anticomplementary activity detectable in vitro in normal kidney supernate is considered a probable cause of the phenomenon. This factor is capable to activate the alternative complement pathway in human serum.

Key words

Complement system Alternative pathway Acute renal failure Hemoconcentration 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Gy. Losonczy
    • 1
  • E. Pósch
    • 1
  • L. Hársing
    • 1
  1. 1.Institute of PathophysiologySemmelweis University Medical SchoolBudapestHungary

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