Research in Experimental Medicine

, Volume 167, Issue 2, pp 149–158 | Cite as

Rat gastric mucosal oxygen tension, ulcer index, plasma gastrin and glucagon following restraint stress. Influence of vagotomy, splanchnicotomy and exogenous secretin

  • P. O. Schwille
  • W. Schellerer
  • H. Steiner
  • M. Reitzenstein
Article

Summary

Restraint stress ulcers in rats were developed and procedures evaluated designed at preservation of intact gastric microcirculation (pO2).

Neither prior truncal vagotomy, splanchnicotomy nor combined dissection of abdominal autonomic nerves were effective in preventing the stress mediated fall of mucosal pO2 and the rise in plasma glucagon. The ulcer index remained elevated and gastrin essentially was unchanged. Prophylactic injection of increasing doses (1, 2, 4, 8, 16 U/kg) secretin maintained microcirculation at pO2-levels subnormal for unstressed animals (Vmax 15.53 mm Hg; Km. 0.99 U/kg), but simultaneously brought about a continuous rise in serum gastrin. Up to 8 U/kg plasma glucagon was higher than in saline control groups reaching a peak value with 2 U/kg when ulcer index showed its nadir. Secretin therapy (4, 8 U/kg) markedly improves both mucosal pO2 and ulcer index.

It is suggested that breakdown of gastric microcirculation may not be solely responsible for stress ulcer development.

Key words

gastric stress ulcer mucosal oxygen tension vagotomy/splanchnicotomy secretin gastrin/glucagon 

Abbreviations

VT

vagotomy

ST

splanchnicotomy

U.I.

ulcer index

pO2

partial oxygen tension of gastric mucosa

pG1

plasma pancreatic glucagon

G

serum gastrin

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Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • P. O. Schwille
    • 1
  • W. Schellerer
  • H. Steiner
  • M. Reitzenstein
  1. 1.Chirurgische Universitätsklinik Mineralstoffwechsel- und HormonlaborMaximiliansplatzErlangenFederal Republic of Germany

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