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Metabolism of maltose during surgery in patients with diabetes mellitus under general anesthesia

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Research in Experimental Medicine

Summary

During a surgical operation under general anesthesia, maltose was administered at a rate of 1g/kg BW to 9 diabetic and 18 non-diabetic patients.

The disappearance curve of maltose from blood was similar between diabetics and non-diabetics. Blood sugar tended to rise but no significant difference was found between the two groups. Lactic acid and pyruvic acid showed a tendency toward a rise, but the change was non-significant. NEFA and uric acid failed to change. Urinary excretion of maltose was not different between diabetics and non-diabetics. After 120 min., urinary excretion of maltose was similar between the two groups, but excretion as glucose was greater in the diabetic group.

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References

  1. AONO, K., HARANO, K., HIROKATA, Y.: Changes of carbohydrate tolerance during surgery — comparison between glucose and maltose. Jap. J. Anesth.23 797 (1974)

    Google Scholar 

  2. BARKER, N., SHREEVE, W.W., SHIPLRY, R.A., INCEFY, G.E., MILLER, M.:14C studies in carbohydrate metabolism I. The oxidation of glucose in normal human subjects. J. biol. Chem.211 575 (1954)

    PubMed  Google Scholar 

  3. BURKER, S.E., SUMMERSON, W.H.: The colorimetric detemination of lactic acid in biological material. J. biol. Chem.138 535 (1941)

    Google Scholar 

  4. DEAN, N., SCHEREINER, G.E., ROBERTSON, J.S.: The velocity of distribution of sucrose between plasma and interstitial fluid with reference of the use of sucrose for the measurement of extracellular fluid in man. J. clin. Invest.30 1463 (1951)

    PubMed  Google Scholar 

  5. DEAN, N., SMITH, H.W.: Fate of insulin and sucrose in normal subjects as determined by urine reinfusion technique. J. clin. Invest.34 681 (1955)

    PubMed  Google Scholar 

  6. FISKE, C.H., SUBBAROW, Y.: The colorimetric determination of phosphorus. J. Biol. Chem.66 375 (1925)

    Google Scholar 

  7. FRIEDMAN, T.E., HAUGEN, G.E.: The determination of keto acids in blood and urine. J. biol. Chem.147 415 (1943)

    Google Scholar 

  8. FUJII, S., OKUDA, H., MATSUDA, I., UENOYAMA, T, FUJIWARA, H.: Studies on maltose, I. Metabolism of maltose. The Saishin-Igaku,27 1584 (1972)

    Google Scholar 

  9. Glucostat enzymatic determination of glucose. Worthington Biochemical Corporation, Freehold, N.J.

  10. ITAYA, K., UI, M.: Colorimetric determination of free fatty acids in biological fluids. J. Lipid Res.6 16 (1965)

    Google Scholar 

  11. KRUPKA, R.M.: Combined effects of maltose and deoxyglucose on fluorodini-trcbenzene inactivation of sugar transport in erythrocytes. Biochim. biophys. Acta282 326 (1972)

    PubMed  Google Scholar 

  12. LACKO, L., BURGER, M.: Interaction of some disaccharises with the carrier system for aldoses in erythrocytes. Biochem. J.83 622 (1962)

    PubMed  Google Scholar 

  13. LONG, C.L., SPENCER, J.L., KINNEY, J.M., GEIGER, J.W.: Carbohydrate metabolism in man; Effect of elective operations and major injury. J. appl. Physiol.31 110 (1971)

    PubMed  Google Scholar 

  14. PRAETORIUS, E.: Uric acid in "Methods of Enzymatic Analysis", p 500 New York: Academic Press 1965

    Google Scholar 

  15. SOLOMON, L.L., JOHNSON, J.E.: Enzymatic microdetermination of glucose in blood and urine. Anal. Chem.31 453 (1959)

    Google Scholar 

  16. WESER, E., SLEISENGER, M.H.: Metabolism of circulating disaccharides in man and the rats. J. clin. Invest.46 499 (1967)

    PubMed  Google Scholar 

  17. YOUNG, J.M., WESER, E.: Effect of insulin on the metabolism of circulating maltose. Endocrinology86 426 (1970)

    PubMed  Google Scholar 

  18. YOUNG, J.M., WESER, E.: The metabolism of circulating maltose in man. J. clin. Invest.50 986 (1971)

    PubMed  Google Scholar 

  19. YOUNG, E.A., WESER, E.: The metabolism of maltose after intravenous injection in normal man and diabetic subjects. J. clin. Endocr.38 181 (1974)

    PubMed  Google Scholar 

  20. VAN HANDEL, E.: Trehalose and maltose in the serum of vertebrates. Comp. Biochem. Physiol.26 561 (1968)

    PubMed  Google Scholar 

  21. WRIGHT, P.D., JOHNSTON, I.D.A.: Insulin secretion and glucose tolerance during and after surgical operation. IRCS Intntl. Res. Commun.1 34 (1973)

    Google Scholar 

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Yoshikawa, K., Oda, T. Metabolism of maltose during surgery in patients with diabetes mellitus under general anesthesia. Res. Exp. Med. 167, 127–138 (1976). https://doi.org/10.1007/BF01851594

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