Summary
Experimentally it has been shown that coumarin is a very effective therapy in the treatment of high protein oedemas. This study reports on the distribution of a single dose of 3-14C-coumarin in rats. Blood levels of coumarin were always much lower than those of the tissues at similar times. The half life of 3-14C-coumarin and its labelled metabolites was found to be about 43 hours. This ties in fairly well with the optimum frequencies of the administration of the drug which was found to be 24 hours. At this time, skin and muscle levels (the tissues most effected in lymphoedema and in thermal oedema) were maximal.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Altman, P. L.: Blood and Other Body Fluids, ed. D. S. Dittmer. Biological Handbook Series No. 7. 1924
Bauer-Staeb, G., Niebes, P.: The Binding of Polyphenols (Rutin and Some of its O--Hydroxyethyl Derivatives) to Human Serum Proteins. Experientia32, 367 (1976)
Booth, A. N., Masri, M. S., Robbins, D. J., Emerson, O. H., Jones, F. T., Deeds, F.: Urinary Metabolites of Coumarin and O-Coumaric Acid. J. Biol. Chem.234, 946 (1959)
Casley-Smith, J. R., Window, J.: Quantitative Morphological Correlations of the Increased Vascular Permeability caused by Burning and Histamine with the effect of the Benzopyrones. Microvasc. Res.11, 279 (1974)
Casley-Smith, J. R.: The Actions of the Benzo-pyrones on the Blood-Tissue-Lymph System. Folia Angiologica (in press) (1976)
Clodius, L.: Secondary Arm Lymphoedema. I. Lymphoedema, ed. L. Clodius. Berlin-Heidelberg-New York: Springer, p. 7 1976
Clodius, L., Deak, L., Piller, N. B.: A New Instrument for the Evaluation of Tissue Tonicity in Lymphoedema. Lymphology9, 1 (1976)
Földi Börcsök, E., Földi, M.: Effect of External Lymph Drainage and of Coumarin treatment on Dextran Oedema. Angiologica9, 99 (1972)
Földi, M.: Diseases of the Lymphatics and Lymph Circulation. Springfield, U.S.A.: Thomas 1969
Furuya, T.: Studies on the Metabolism of Naturally Occurring Coumarin. V. Urinary Metabolites of Coumarin and Di-hydroxy-coumarin. Chem. Pharm. Bull.6, 701 (1958)
Garten, S., Wosilait, W. D.: Comparative Study of the Binding of Coumarin Anti-coagulants and Serum Albumins. Biochem. Pharmacol.20, 1661 (1971)
Kaighen, M., Williams, R. T.: The Metabolism of 3-14C-Coumarin. J. Med. Pharm. Chem.3, 25 (1961)
Kovach, A. G. B., Foldi, M., Szlamka, I., Ecker, A., Hamori, M.: The Effect of Esberiven — a Melilotus Preparation — on the Activity of the Reticulo-endothelial System. Ärztl. Forsch.19, 610 (1965)
Mayerson, H. S.: Importance of Lymph flow in normal functioning of body. In: “Handbook of Physiology”. Circulation II, ed. W. F. Hamilton and P. Dow. Baltimore: Waverley Press 1963
O'Reilly, R. H., Interaction of Several Coumarin Compounds with Human and Canine Plasma Albumin. Mol. Pharmacol.7, 209 (1971)
Piller, N. B.: The Resolution of Thermal Oedema at Various Temperatures under Coumarin Treatment. Br. J. Exp. Path.56, 83 (1975a)
Piller, N. B.: A Comparison of the Effectiveness of Some Anti-inflammatory Drugs on Thermal Oedema. Br. J. Exp. Path.56, 554 (1975b)
Piller, N. B., Casley-Smith, J. R.: The Effect of Coumarin on Protein and PVP Clearance from Rat Legs with Various High Protein Oedemas. Br. J. Exp. Path.56, 439 (1975)
Piller, N. B.: A Comparison of the Effect of Benzo-pyrones and other Drugs with Anti-inflammatory Properties on Acid and Neutral Protease Activity Levels in Various Tissues after Thermal Injury. Br. J. Exp. Path.57, 411 (1976a)
Piller, N. B.: Drug Induced Proteolysis: A Correlation with Oedema-Reducing Ability. Br. J. Exp. Path.57, 266 (1976b)
Piller, N. B.: A Conservative Means of Reducing the Intensity and Duration of Thermally Induced Oedema. Burns2, 143 (1976c)
Piller, N. B.: The Effect of Coumarin on the Liver weight of Thermally Injured Rats. Res. Exp. Med.169, 29 (1976)
Piller, N. B.: The Influence of Coumarin on Blood Levels of Radio Labelled Protein and Radio Labelled Poly-vinyl pyrrolidone in Thermally Injured Rats. Res. Exp. Med.168, 165 (1976)
Piller, N. B.: Tissue Levels of (3-14C) Coumarin in the rat: Their Distribution and Excretion. Br. J. Exp. Path.58, 28 (1976f)
Piller, N. B.: The Influence of Coumarin on Tissue Levels of Radio Labelled Plasma — Protein and Povidone (poly-vinyl pyrrolidone) in Normal and Thermally Injured Rats. Clin. Exper. Pharmacol. Physiol.3, 11 (1976g)
Piller, N. B.: Benzo-pyrone Treatment of Mild Thermal Oedema: Determination of the Most Effective Dose. Folio Angiologica (in press) (1976h)
Piller, N. B., Clodius, L.: Clinical Effectiveness of Venalot® on Primary and Secondary Lymphoedema. Europ. J. Clin. Invest. (submitted for publication) (1976a)
Piller, N. B., Clodius, L.: The Use of a Tissue Tonometer as a Diagnostic Aid in Lymphoedema: A Determination of its Conservative Treatment with Benzo-pyrones. Lymphology9, 127 (1976b)
Shilling, W. N., Crampton, R. F., Longland, R. C.: The Metabolism of Coumarin in Man. Nature221, 665 (1969)
Sumere, Van C. F., Teuchy, H.: The Metabolism of (2-14C) Coumarin and (2-14C) hydroxycoumarin in the Rat. Arch. Int. Physiol. Biochem.79, 665 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Piller, N.B. (3-14C) coumarin distribution in rat tissues after the injection of a single dose. Res. Exp. Med. 171, 93–100 (1977). https://doi.org/10.1007/BF01851592
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01851592