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Research in Experimental Medicine

, Volume 171, Issue 1, pp 79–92 | Cite as

Die Wirkungβ-adrenerger Substanzen auf die exokrine Funktion des Pankreas

Untersuchungen am isoliert perfundierten Pankreas der Katze
  • E. Heidbreder
  • P. Sieber
  • A. Heidland
Article

Zusammenfassung

Die Wirkung verschiedenerβ-sympathomimetischer Substanzen auf die exokrine Pankreasfunktion wurde im Vergleich zur Wirkung des Acetylcholins am isoliert perfundierten Pankreas der Katze untersucht. Alle Substanzen führten zu einer deutlichen Mehrausscheidung von Protein und Enzymen, während die hydrokinetische Funktionskomponente (Saftvolumen, Calciumausscheidung) sich kaum änderte. Die Proteinsekretion war sowohl durch verschiedene adrenolytische Substanzen (Phenoxybenzamin, Practolol, Butoxamin) als auch durch Tetracain, Hemicholinium und Atropin hemmbar. Das Pankreas zuvor mit Reserpin oder 6-Hydroxydopamin vorbehandelter Tiere zeigte keine Funktionseinschränkung. Aus den Untersuchungen wird geschlossen, daßβ-adrenerge Substanzen die Pankreasfunktion cholinerg beeinflussen. Die Ergebnisse bestätigen andere Untersuchungen über die Hemmbarkeit der Isoproterenol-induzierten Amylasesekretion durch Atropin.

Schlüsselwörter

β-Sympathomimetica α-Sympatholytica β-Sympatholytica Antisympathotonica Tetracain Hemicholinium Exokrine Pankreasfunktion 

The effect of sympathomimetic drugs on exocrine pancreatic function. Studies in the isolated cat pancreas

Summary

This study reports on effects ofβ-sympathomimetic drugs on the exocrine function of the isolated cat pancreas. The injection of these drugs resulted in an increase of pancreatic protein and enzyme secretion, the excretion of calcium into the juice and the rate of volume output were not changed. The enzyme secretion was inhibited by different adrenolytic drugs (phenoxybenzamine, practolol, butoxamine), by tetracain, hemicholinium, and atropine. The pancreatic function of cats pretreated by reserpine or 6-hydroxydopamine was not altered. It is concluded, thatβ-sympathomimetic drugs influence the pancreatic protein and enzyme secretion in a cholinergic way. These results are consistent with those of other investigators showing a suppressibility of the isoproterenol-induced pancreatic amylase secretion by atropine.

Key words

β-sympathomimetics α-sympatholytic drugs β-sympatholytic drugs Reserpine 6-hydroxydopamine Tetracain Hemicholinium Atropine Exocrine pancreatic function 

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • E. Heidbreder
    • 1
  • P. Sieber
    • 1
  • A. Heidland
    • 1
  1. 1.Medizinische Universitätsklinik WürzburgWürzburgGermany

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