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The circulation in liver tissue and experimental liver metastases before and after embolization of the liver artery

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Research in Experimental Medicine

Summary

Simultaneous measurement of cardiac output distribution with86Rubidium and57Cobalt-tagged microspheres in rats implanted with liver tumors by intraportal injection of sarcoma cells enables quantitation of arterial and portal tumor circulation. The portal circulation was found to be increased in small tumors as compared to the liver, but as the tumor grew there was a decrease in the portal tumor circulation. When the tumor growth became massive even the total liver circulation was reduced, as measured with133Xenon wash-out. All the tumors had increased arterial circulation. This arterial hyperperfusion was changed into ischemia when the liver artery was occluded through embolization with degradable microspheres.

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Authors and Affiliations

  1. Experimental Department, Department of Nuclear Medicine, Department of Surgery and Wallenberg Laboratory, University of Lund, Malmö General Hospital, S-21401, Malmö, Sweden

    Bo Lindell, Karl Fredrik Aronsen, Ulf Rothman & Hans O. Sjögren

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  1. Bo Lindell
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  2. Karl Fredrik Aronsen
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  3. Ulf Rothman
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  4. Hans O. Sjögren
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Lindell, B., Aronsen, K.F., Rothman, U. et al. The circulation in liver tissue and experimental liver metastases before and after embolization of the liver artery. Res. Exp. Med. 171, 63–70 (1977). https://doi.org/10.1007/BF01851589

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  • DOI: https://doi.org/10.1007/BF01851589

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