Research in Experimental Medicine

, Volume 161, Issue 4, pp 327–334 | Cite as

The influence of l-(5-oxohexyl-)3.7-dimethylxanthine (BL 191) on the endocrine and exocrine pancreatic function in man during and following secretin and cholecystokinin-pancreozymin stimulation

  • H. C. Dollinger
  • S. Raptis
  • B. Grebe
  • H. Goebell
  • R. Müller
  • H. J. Hinze
  • E. F. Pfeiffer
Article

Summary

The intravenous administration of secretin or cholecystokinin-pancreozymin alone led to a short rapid rise in radio-immunologically measurable insulin, and to a stimulation of the hydrokinetic as well as the ecbolic, exocrine pancreatic function.

During the administration of 1-(5-oxohexyl-)-3.7-dimethylxanthine (BL 191) no significant change in the endocrine and exocrine pancreatic secretion was registered, compared to the secretin injection alone, whereas BL 191 was able to inhibit the insulin and enzyme secretion after the administration of cholecystokinin-pancreozymin.

The influence neither of secretin nor cholecystokinin-pancreozymin on the endocrine as well as the exocrine pancreas seems to be mediated directly by cyclic 3′-5′ adenosine monophosphate (cAMP), and the decrease of endocrine and exocrine pancreatic secretion, induced by cholecystokinin-pancreozymin during administration of BL 191, is probably due to an inhibition of the alpha-receptor system. Additional experiments are required for further elucidation of these conclusions.

Key words

Methylxanthines Phosphodiesterase Cyclic AMP Intestinal hormones Endocrine pancreas Exocrine pancreatic function Adrenergic alpha-receptors 

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • H. C. Dollinger
    • 1
    • 2
  • S. Raptis
    • 1
  • B. Grebe
    • 1
  • H. Goebell
    • 1
  • R. Müller
    • 1
  • H. J. Hinze
    • 1
  • E. F. Pfeiffer
    • 1
  1. 1.Section of Gastroenterology and the Department of Internal Medicine, Endocrinology and Metabolism, Center of Internal Medicine and PediatricsUniversity of UlmW Germany
  2. 2.Zentrum für Innere Medizin und KinderheilkundeUlmFederal Republic of Germany

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