Summary
The study was carried out in anesthetized, intubated and spontaneously breathing dogs. The aim of this study was to examine the responsiveness of the tracheo-bronchial system to inhalative ACh. It was considered that any change in ACh-sensitivity signifies the involvement of receptors in the lung itself.
Increased pressure in the right heart and main pulmonary artery did not affect the ACh-sensitivity. Whereas, the sustained pulmonary vascular congestion produced by blocking the ascending aorta or by glass bead embolism provoked greater ACh-sensitivity. Increased ACh-sensitivity was also observed in unilateral pulmonary artery occlusion. ACh-sensitivity was greater in the later part of occlusion or vascular congestion and persisted even after the occlusion or block was withdrawn. It is concluded that the increased ACh-sensitivities in pulmonary vascular congestion and in unilateral pulmonary artery occlusion are due to the formation of edema and atelectasis respectively. Anyway, the disturbance of the metabolism of the receptor cells around the small vessels of the lung circulation seems to be essential.
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Armstrong, B. W., Hurt, H. H., Blide, R. W., Worman, J. M.: The humoral regulation of breathing. Sciences133, 1906 (1961)
Aviado, D. M., Li, T. H., Kalow, W., Schmidt, C. F., Turnbull, G. O., Peskin, F. W., Hess, M. E., Weiss, A. J.: Respiratory and circulatory reflexes from the perfused heart and pulmonary circulation of the dog. Amer. J. Physiol.165, 267 (1951)
Borst, H. G., Berglund, E., Wittenberger, J. L., Mead, J., McGregor, M., Collier, C.: The effect of pulmonary vascular pressures on the mechanical properties of the lungs of anesthetized dogs. J. Clin. Invest.36, 1708 (1957)
Bruderman, I., Rogel, S.: Changes in ventilation and pulmonary mechanics induced by hypertonic sodium chloride. J. appl. Physiol.21, 383 (1966)
Cahill, J. M., Byrne, J. J.: Ventilatory mechanics in hypervolumic shock. J. appl. Physiol.19, 679 (1964)
Chavez, F. R., Harris, J. O., Swenson, E. W., Daicoff, G. R., Anton, A. H.: Pulmonary venous hypertension, edema and the altered function of the lung after embolization with autologous clots. Int. Symp. on Pulmonary Circulation. Prague 1969, Progr. Resp. Res. by Widimsky, J. S. Daum and H. Herzog, p. 264, 1970
Constantin, L. L.: Effect of pulmonary congestion on vagal afferent activity. Amer. J. Physiol.196, 49 (1959)
Cook, C. D., Mead, J., Schreiner, G. L., Frank, N. R., Craig, J. M.: Pulmonary mechanics during induced pulmonary edema in anesthetized dogs. J. appl. Physiol.14, 177 (1959)
Daley, I. De B., Ludany, G., Todd, A., Verney, E. R.: Sensory receptors in the pulmonary vascular bed. Quart. J. exp. Physiol.27, 123 (1937)
Dawes, G. S., Comroe, J. H.: Chemoreflexes from the heart and lung. Physiol. Rev.34, 167 (1954)
Dowing, S. E.: Reflex effect of acute hypertension in the pulmonary vascular bed of the dog. Yale J. Biol. Med.30, 43 (1957)
Duke, H. N., Green, J. H., Heffron, P. F.: Pulmonary chemoreceptors. Quart. J. exp. Physiol.48, 164 (1963)
Glogowska, M., Widdicombe, J. G.: The role of vagal reflexes in experimental lung oedema, bronchoconstriction and inhalation of halothane. Respiration Physiology18, 116 (1973)
Islam, M. S., Ulmer, W. T.: Über die Rolle von Serotonin als Bronchokonstriktor. Pneumonologie148, 135 (1973)
Islam, M. S., Ulmer, W. T.: Prostaglandin F2 alpha als Bronchokonstriktor. Respiration31, 332 (1974)
Islam, M. S., Ulmer, W. T.: Lokale Überempfindlichkeit sensorischer Rezeptoren als Ursache reflektorischer Atemwegobstruktion. Respiration32, 445 (1975)
Islam, M. S., Rasche, B., Vastag, E., Ulmer, W. T.: Empfindlichkeitssteigerung der Bronchialmuskulatur durch proteolytische Fermente im Sputum. Pneumonologie146, 232 (1971)
Islam, M. S., Vastag, E., Ulmer, W. T.: Effect of noxious stimulants on bronchial reactivity. Bull. Physio.-path. resp.8, 509 (1972a)
Islam, M. S., Rasche, B., Vastag, E., Ulmer, W. T.: Über den Wirkungsmechanismus von Histamin in den Atemwegen. Respiration29, 538 (1972b)
Islam, M. S., Ulmer, W. T., Kniefeld, W.: Lungenfunktion bei Spannungsverlust der Lunge. Pneumonologie151, 73 (1974)
Islam, M. S., Zimmermann, I., Ulmer, W. T.: The role of unilateral vagotomy on reflex bronchoconstriction. Pneumonologie152, 281 (1975)
Islam, M. S., Zimmermann, I., Ulmer, W. T.: Relationship between pulmonary embolism, airway obstruction and hypersensitivity of the airway in dog and influence of partial vagus nerve blockade. Respiration (1976) (in press)
Marshall, R., Widdicombe, J. G.: The activity of pulmonary stretch receptors during congestion of the lung. Quart. J. exp. Physiol.43, 320 (1958)
Nadel, J. A., Colebatch, J. H., Olsen, C. R.: Location and mechanism of airway constriction after barium sulfate micro-embolism. J. appl. Physiol.19, 387 (1964)
Paintal, A. S.: Impulses in vagal afferent fibres from specific pulmonary deflation receptors. Quart. J. exp. Physiol.40, 89 (1955)
Paintal, A. S.: Mechanism of stimulation of type J-pulmonary receptors. J. Physiol. (Lond.)203, 511 (1969)
Paintal, A. S., Riley, R. L.: Responses of aortic chemoreceptors. J. appl. Physiol.21, 543 (1966)
Riley, R. L., Dutton, R. E. jr., Fuleihan, F. L. D., Nath, S., Hurt, H. H. jr., Joshimoto, C., Sipple, J. H., Permutt, S., Bromberger-Barnea, B.: Regulation of respiration and blood gases. Ann. N.Y. Acad. Sci.109, 829 (1963)
Said, S. I., Longachar, J. W. jr., Davis, R. K., Banerjee, C. M., Davis, W. M., Wooddell, W. J.: Pulmonary gas exchange during induction of pulmonary edema in anesthetized dogs. J. appl. Physiol.19, 403 (1964)
Sellick, J., Widdicombe, J. G.: The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion. J. Physiol. (Lond.)203, 359 (1969)
Severingshaus, J. W., Swenson, E. W., Finley, T. N., Lategola, M. T., Williams, J.: Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. J. appl. Physiol.16, 55 (1961)
Swenson, E. W., Finley, T. N., Guzman, S. V.: Unilateral hypoventilation in man during temporary occlusion of one pulmonary artery. J. Clin. Invest.40, 828 (1961)
Schwiegk, H.: Der Lungenentlastungsreflex. Pflügers Arch. ges. Physiol.236, 206 (1935)
Ulmer, W. T., Islam, M. S.: Die Acetylcholinempfindlichkeit des Bronchialbaumes. Respiration31, 137 (1974)
Ulmer, W. T., Islam, M. S., Bakran, I. jr.: Untersuchungen zur Ursache der Atemwegsobstruktion und des überempfindlichen Bronchialsystems. Dtsch. med. Wschr.96, 1759 (1971)
Widdicombe, J. G.: Regulation of tracheo-bronchial smooth muscle. Physiol. Rev.43, 1 (1963)
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This Research was supported by the Commission of the European Communities for Coal and Steel, Luxembourg
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Islam, M.S., Ulmer, W.T. Mechanism of increased tracheo-bronchial response to inhalative acetylcholine aerosol in pulmonary vascular congestion and unilateral pulmonary artery occlusion. Res. Exp. Med. 170, 229–239 (1977). https://doi.org/10.1007/BF01851433
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DOI: https://doi.org/10.1007/BF01851433