Research in Experimental Medicine

, Volume 170, Issue 3, pp 211–215 | Cite as

Hydroxyproline fractions in serum and urine of rats during wound healing

  • M. Nagelschmidt
  • H. Struck


Total hydroxyproline in urine and free hydroxyproline, free and peptide hydroxyproline and protein bound hydroxyproline in serum are measured during wound healing in rats. The free and free + peptide fractions vary in concert with each other and with urine hydroxyproline. Protein bound hydroxyproline fractions take a very different course and behave as an acute phase reactant. The results suggest that protein bound hydroxyproline does not mirror collagen turnover but may be more relevant to C1q or complement metabolism.

Key words

Hydroxyproline Complement Wound healing Rats 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • M. Nagelschmidt
    • 1
  • H. Struck
    • 1
  1. 1.Biochemical and Experimental Division, II. Department of SurgeryUniversity of CologneKöln-MerheimFederal Republic of Germany

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