Research in Experimental Medicine

, Volume 166, Issue 1, pp 35–42 | Cite as

Immunopathological lymph node findings in Hodgkin's disease correlation to survival

  • Piero Tosi
  • Marcella Cintorino
  • Pietro Luzi


217 diagnostic lymph nodes biopsies from cases of Hodgkin's disease were classified according to the criteria established by the Rye Conference. These were later subdivided into survival groups using immunopathological parameters solely. In the light of findings based upon 63 cases whose progress has been followed, it appears that the classification of Hodgkin's disease according to immunopathological parameters may serve to eliminate many of the inconsistencies encountered with the utilization of classical procedures, especially in the correlation between histopathological analysis and prognosis.

The new classification consists of three groups:

  1. I.

    Long survivals (>5 years): extensive lymph node preservation of antibody mediated (average ~ 65%) and cell mediated (average ~ 37%) immunity, and/or a nodular birefringent fibrosis-hyalinosis. - - - (15,9%)

  2. II.

    Medium survivals (≤ 5 > 2 years): partial lymph nodes preservation of antibody mediated (average ~ 42%) and/or cell mediated (average ~ 17%) immunity, and/or numerous epithelioid cell infiltrates in paracortical areas. (42,9%)

  3. III.

    Short survivals (≤ 2 years): minimal lymph node antibody mediated (average ~ 7%) and cell mediated (average ~ 1%) immunological activity, no epithelioid cell infiltrates and no birefringent fibrosis-hyalinosis. - - - (41,2%)


Key words

Hodgkin's disease Lymph nodes Pathology Immunopathology Diagnosis 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • Piero Tosi
    • 1
    • 2
  • Marcella Cintorino
    • 1
  • Pietro Luzi
    • 1
  1. 1.Institute of Morbid Anatomy and HistologyUniversity of SienaItaly
  2. 2.Istituto di Anatomia e Istologia PatologicaSienaItaly

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