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Evaluation of133Xe clearance curves in the study of lingual blood flow in dogs

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Research in Experimental Medicine

Summary

Lingual blood flow was studied in dogs by the133Xe clearance technique under control conditions, during epinephrine infusion and in response to the combined treatment with Regitin and epinephrine. The composite washout curves recorded during control conditions could be resolved into three monoexponential components. It is suggested that the steep initial slope (component I) is caused by the fraction of blood that perfuses the A-V anastomoses of the tongue. Components II and III appear to indicate the perfusion rate of lingual mucosa and musculature, respectively. The disappearance of component I due to the effect of epinephrine infusion might indicate the closure of arterio-venous anastomoses containing alpha receptors. Regitin pretreatment could prevent the closure of the arterio-venous anastomoses elicited by epinephrine infusion. The beta receptor stimulating activity of epinephrine might account for the augmentation of blood flow to lingual musculature.

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Authors and Affiliations

  1. Institute of Pathophysiology, Semmelweis University Medical School, Nagyvárad tér 4., H-1089, Budapest, Hungary

    Á. Fazekas, E. Pósch & L. Hársing

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  1. Á. Fazekas
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  2. E. Pósch
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  3. L. Hársing
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Fazekas, Á., Pósch, E. & Hársing, L. Evaluation of133Xe clearance curves in the study of lingual blood flow in dogs. Res. Exp. Med. 175, 271–278 (1979). https://doi.org/10.1007/BF01851283

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  • DOI: https://doi.org/10.1007/BF01851283

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