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Versuch der biochemischen Beeinflussung der Frakturheilung im Tierexperiment

Experimental acceleration of fracture repair by biochemical media

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Research in Experimental Medicine

Summary

The influence of calcitonine, amino acids, ribonucleid acids, kallikrein, growth hormone, and cyclic adenosine 3′5′ monophosphate on fracture repair was tested in rabbits. To obtain an objective measurement of callus stability the bones were bent mechanically. The force applied and the degree of bending were recorded continuously. The slope of the curve was taken as a parameter of callus stability. In the series with calcitonine no influence on fracture healing was found. Injections of ribonucleic acids, amino acids, kallikrein, and growth hormone demonstrated a limited effect on bone repair. Callus formation was stimulated by adenosine 3′5′ monophosphate. Optimal results were achieved by a combination of adenosine 3′5′ monophosphate, amino acids, ribonucleic acids, and kallikrein.

Zusammenfassung

In Tierversuchen wurde der Einfluß von Calcitonin, Ribonucleinsäuren, Aminosäuren, Kallikrein, Wachstumshormon und cyclischem Adenosin 3′5′ monophosphat auf die Heilung von Tibiafrakturen der Kaninchen geprüft. Um objektive Meßergebnisse der Callusstabilität zu erhalten, wurden die Knochen maschinell bis zur Refraktur gebogen. Die angewandte Kraft und der Grad der Durchbiegung wurden fortlaufend gemessen und in Kurven aufgetragen. Der Anstiegswinkel der erzielten Kurven galt als Parameter der Callusstabilität. Versuche mit Calcitonin zeigten keinen Effekt auf die Knochenbruchheilung. Injektionen von Ribonucleinsäuren, Aminosäuren, Kallikrein und Wachstumshormon ließen einen begrenzten Einfluß auf die Callusfestigung erkennen. Eine Verbesserung der Frakturheilung wurde durch cyclisches Adenosin 3′5′ monophosphat erreicht. Durch die Kombination von cyclischem Adenosin 3′5′ monophosphat mit Aminosäuren, Ribonucleinsäuren und Kallikrein wurde ein optimales Resultat erzielt.

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  1. Abteilung für Allgemeinchirurgie, Chirurgische Universitätsklinik und Poliklinik Hamburg-Eppendorf, D-2000, Hamburg-Eppendorf, Bundesrepublik Deutschland

    Jörn F. J. Bethge, R. Babayan, H. P. Borm, R. v. Fehrentheil, H. ten Hoff, H. Hose, P. Mangels, H. Piening, C. Reimers & U. Wider

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Bethge, J.F.J., Babayan, R., Borm, H.P. et al. Versuch der biochemischen Beeinflussung der Frakturheilung im Tierexperiment. Res. Exp. Med. 175, 197–222 (1979). https://doi.org/10.1007/BF01851277

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