Summary
The effects of combined treatment with a heparinoid-sodium pentosan polysulfate — and an antihistamine-promethazine hydrochloride — against thioacetamide-induced rat liver injury were studied.
Treatment by promethazine hydrochloride at 0 and 6 hrs by 2.5 and 1.25 mg per 100 g body weight or by 1.5 mg pentosan polysulfate did not afford a real protection against liver injury. The combined, however, of these two incompletely acting schedules treatment inhibited substantially the development of liver cellnecrosis up to 96 hrs. A synergic action of the above protective agents could be supposed.
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This study has been supported by “G. Lyras” grant to whom the first author expresses his thanks.
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Bartsokas, S.K., Papacharalampous, N.X., Papadimitriou, D.G. et al. Synergia of a heparinoid and promethazine hydrochloride against liver cell necrosis. Res. Exp. Med. 162, 235–241 (1974). https://doi.org/10.1007/BF01851245
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DOI: https://doi.org/10.1007/BF01851245